{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:47:58Z","timestamp":1732034878256},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this issue, Hellmann\u2010Regen <jats:italic>et\u00a0al<\/jats:italic>. suggested that anti\u2010acne effects of erythromycin and tetracyclines may be related to their inhibitory effect of cytochrome P450\u2010mediated degradation of <jats:italic>all\u2010trans<\/jats:italic>\u2010retinoic acid (ATRA). We have recently proposed that all anti\u2010acne agents function by attenuation of increased <jats:styled-content style=\"fixed-case\">mTORC<\/jats:styled-content>1 signalling. This commentary links the P450 system to <jats:styled-content style=\"fixed-case\">mTORC<\/jats:styled-content>1 regulation in acne. Drug\u2010mediated induction of P450 activity or P450 mutants with increased catabolic activity may reduce cellular ATRA levels and FoxO1 expression, thus reducing FoxO\u2010mediated <jats:styled-content style=\"fixed-case\">mTORC<\/jats:styled-content>1 inhibition. In contrast, agents blocking ATRA degradation such as erythromycin and tetracyclines may improve acne by increasing FoxO1 expression with consecutive inhibition of <jats:styled-content style=\"fixed-case\">mTORC<\/jats:styled-content>1 signalling.<\/jats:p>","DOI":"10.1111\/exd.12359","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T11:52:22Z","timestamp":1393847542000},"page":"318-319","source":"Crossref","is-referenced-by-count":10,"title":["The P450 system and <scp>mTORC<\/scp>1 signalling in acne"],"prefix":"10.1111","volume":"23","author":[{"given":"Bodo C.","family":"Melnik","sequence":"first","affiliation":[{"name":"Department of Dermatology Environmental Medicine and Health Theory University of Osnabr\u00fcck Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23307.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12358"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.02.041"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700432"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1230"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.12.004"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0937-7"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.58.6.1341"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017855"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(03)00042-3"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RG-134"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190031"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00066.x"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00868.x"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12471782"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.15331"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22417"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.03.013"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.03.008"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.125773"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.19828"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12142"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12172"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.2013.846514"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.323303"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.08.007"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.02.006"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.2165\/11588900-000000000-00000"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.852297"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12359","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:34:49Z","timestamp":1695540889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,28]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/exd.12359"],"URL":"https:\/\/doi.org\/10.1111\/exd.12359","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,28]]}}}