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Despite advances in naevus and melanoma biology, the location and differentiation status of the cell of origin remains undefined. Germ line genetics, biological state and cellular location of the mutated cell, as well as local environmental factors all likely play a role in the development of melanocytic neoplasms. Herein, we will review potential models for melanocytic neoplasia and discuss research challenges and opportunities.<\/jats:p>","DOI":"10.1111\/exd.12363","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T16:22:44Z","timestamp":1393863764000},"page":"310-313","source":"Crossref","is-referenced-by-count":26,"title":["How, and from which cell sources, do nevi really develop?"],"prefix":"10.1111","volume":"23","author":[{"given":"James M.","family":"Grichnik","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"},{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami FL USA"},{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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