{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:07:28Z","timestamp":1790381248525,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is an acquired depigmentation disorder characterized by the loss of functional melanocytes from the epidermis. Two major theories of vitiligo pathogenesis include autoimmunity and oxidative stress\u2010mediated toxicity in melanocytes. The present study aimed to evaluate both the hypotheses in vitiligo patients and to investigate their role in the disease onset and progression. Antimelanocyte antibody levels and lipid peroxidation (<jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content>) levels were evaluated in 427 patients and 440 controls; antithyroid peroxidase (<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>) antibody levels were estimated in 102 patients and 72 controls. Patients showed a significant increase in <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content> and antimelanocyte antibody levels compared to controls. Antimelanocyte antibody and <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content> levels were higher in active vitiligo compared to stable. Only 9.8% of patients showed the presence of anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> antibodies in their circulation. Oxidative stress may be the initial triggering event to precipitate vitiligo in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ujarat population, which is exacerbated by contributing autoimmune factors together with oxidative stress.<\/jats:p>","DOI":"10.1111\/exd.12372","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T11:19:46Z","timestamp":1394795986000},"page":"352-353","source":"Crossref","is-referenced-by-count":60,"title":["Role of oxidative stress and autoimmunity in onset and progression of vitiligo"],"prefix":"10.1111","volume":"23","author":[{"given":"Naresh C.","family":"Laddha","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Science The Maharaja Sayajirao University of Baroda Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitesh","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Science The 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