{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:21:12Z","timestamp":1790803272746,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis is a chronic inflammatory cutaneous disease with difficult\u2010to\u2010treat pruritus. Although phosphodiesterase (\n                    <jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>\n                    ) 4 inhibitors have an anti\u2010inflammatory effect on inflammatory skin diseases, such as atopic dermatitis, their acute antipruritic activities remain unclear. Therefore, in this study, we examined whether\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    6005, a novel\n                    <jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>\n                    4 inhibitor, has antipruritic activity in dermatitis, using a mouse model of atopic dermatitis (\n                    <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                    ga mice). A single topical application of\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    6005 inhibited spontaneous hind\u2010paw scratching, an itch\u2010associated response and spontaneous activity of the cutaneous nerve in mice with chronic dermatitis. The cutaneous concentration of c\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    was significantly decreased in mice with chronic dermatitis, and this decrease was reversed by topical\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    6005 application. These results suggest that\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    6005 increases the cutaneous concentration of c\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    to relieve dermatitis\u2010associated itching. Thus,\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    6005 may be a useful therapy for pruritic dermatitis such as atopic dermatitis.\n                  <\/jats:p>","DOI":"10.1111\/exd.12377","type":"journal-article","created":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T15:28:10Z","timestamp":1395242890000},"page":"359-361","source":"Crossref","is-referenced-by-count":33,"title":["Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch\u2010related responses in mice with chronic atopy\u2010like dermatitis"],"prefix":"10.1111","volume":"23","author":[{"given":"Tsugunobu","family":"Andoh","sequence":"first","affiliation":[{"name":"Department of Applied Pharmacology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kuraishi","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01024.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00766.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.057"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08332FP"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01346.x"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.155"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(99)80068-4"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.57.12.0011"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152807780077318"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.09.011"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.03.007"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12297888"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.205542"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(00)00099-2"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.90.193"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00114.x"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312568200"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00440-3"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.02.029"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.08.006"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.03.001"},{"key":"e_1_2_2_24_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","volume":"9","author":"Matsuda H","year":"1997","journal-title":"Int Immunol"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12222"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152807780077318"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.05.038"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00181-9"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00802-4"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T03:35:11Z","timestamp":1695526511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,28]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/exd.12377"],"URL":"https:\/\/doi.org\/10.1111\/exd.12377","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,28]]}}}