{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:52:27Z","timestamp":1790776347955,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non\u2010equilibrium atmospheric pressure plasmas (NEAPP<\/jats:styled-content>s) in vitro<\/jats:italic>. Here, we examined the in vivo<\/jats:italic> effect of NEAPP<\/jats:styled-content> on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP<\/jats:styled-content> irradiation decreased expression levels of cell cycle promoters, Cyclin D1<\/jats:italic>, E1<\/jats:italic> and E2,<\/jats:italic> and increased expression level of a cell cycle repressor, p27<\/jats:italic>KIP<\/jats:italic><\/jats:sup><\/jats:styled-content>1<\/jats:italic><\/jats:sup>. Cyclin D1<\/jats:italic>, E1<\/jats:italic> and E2<\/jats:italic> and p27<\/jats:italic>KIP<\/jats:italic><\/jats:sup><\/jats:styled-content> expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP<\/jats:styled-content> irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.<\/jats:p>","DOI":"10.1111\/exd.12415","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T08:30:26Z","timestamp":1398069026000},"page":"424-425","source":"Crossref","is-referenced-by-count":38,"title":["Non\u2010equilibrium atmospheric pressure plasmas modulate cell cycle\u2010related gene expressions in melanocytic tumors of RET<\/scp>\u2010transgenic mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Ichiro","family":"Yajima","sequence":"first","affiliation":[{"name":"Unit of Environmental Health Sciences Department of Biomedical Sciences College of Life and Health Sciences Chubu University Kasugai Aichi Japan"},{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko Y.","family":"Kumasaka","sequence":"additional","affiliation":[{"name":"Unit of Environmental Health Sciences Department of Biomedical Sciences College of Life and Health Sciences Chubu University Kasugai Aichi Japan"},{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Omata","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine Nagoya Aichi 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Electrical Engineering and Computer Science Graduate School of Engineering Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Unit of Environmental Health Sciences Department of Biomedical Sciences College of Life and Health Sciences Chubu University Kasugai Aichi Japan"},{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine Nagoya Aichi 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