{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:01:46Z","timestamp":1791950506723,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["20390308, 20591331, 21659271, 23591634, 23791298, 23791299, 23791300, 23791301, 24659534, 245916"],"award-info":[{"award-number":["20390308, 20591331, 21659271, 23591634, 23791298, 23791299, 23791300, 23791301, 24659534, 245916"]}]},{"name":"Supported Program for the Strategic Research Foundation at Private Universities from the Ministry of Education, Culture, Sports, Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>B\u2010cell activating factor (<jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content>), an important immune regulatory cytokine, is involved in development of autoimmune diseases. Although <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> is expressed in various cells, including dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s) and monocytes, <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> expression on <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells has not been well documented. In the present study, <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> molecules on <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s and na\u00efve and memory <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells in autoimmune bullous diseases, including pemphigus vulgaris, pemphigus foliaceus and bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), were analysed by flow cytometry. Compared with healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> expression on na\u00efve and memory <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells increased significantly in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. No difference in <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> receptor expression in na\u00efve and memory <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells was shown among all study groups. Furthermore, <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> expression in both na\u00efve and memory <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, but not <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, was detected by confocal microscopic analysis. These results implied that <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> expressed by <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells may play a pathogenic role in autoimmune bullous diseases, particularly <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.12421","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T18:00:47Z","timestamp":1398276047000},"page":"596-605","source":"Crossref","is-referenced-by-count":13,"title":["B\u2010cell activating factor detected on both na\u00efve and memory <scp>B<\/scp> cells in bullous pemphigoid"],"prefix":"10.1111","volume":"23","author":[{"given":"Hua","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Fukuoka 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