{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:12:03Z","timestamp":1790730723637,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Xerosis is one of the most common dermatologic disorders occurring in the elderly and in patients with atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) and human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) infection. Xerosis has been linked to an impaired skin barrier function of the stratum corneum. Using <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>aman microspectroscopy, we concentrated on deeper skin layers, viable epidermis and dermis of 47 volunteers and associated molecular alterations to the evolution of xerosis and the skin barrier, for example, lipid, water and antioxidant content. A decrease in lipids within the viable epidermis is found for elderly and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010patients. Lipid and water values of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients and their healthy reference group are similar. Decreases in lipids and simultaneous increases in water are found in the dermis for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients in comparison to their healthy reference groups. Excessive levels of epidermal carotenoids, mainly lycopene, in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010patients were found potentially leading to adverse effects such as premature skin ageing.<\/jats:p>","DOI":"10.1111\/exd.12425","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T18:03:39Z","timestamp":1398276219000},"page":"446-448","source":"Crossref","is-referenced-by-count":18,"title":["Similar appearance, different mechanisms: xerosis in <scp>HIV<\/scp>, atopic dermatitis and ageing"],"prefix":"10.1111","volume":"23","author":[{"given":"Meike","family":"Mischo","sequence":"first","affiliation":[{"name":"Physical Chemistry II Ruhr\u2010Universit\u00e4t Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"von Kobyletzki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Clinical Research in Malm\u00f6 Lund University Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Public Health Sciences Karlstad University Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Br\u00fcndermann","sequence":"additional","affiliation":[{"name":"Physical Chemistry II Ruhr\u2010Universit\u00e4t Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diedrich A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Physical Chemistry II Ruhr\u2010Universit\u00e4t Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Potthoff","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert H.","family":"Brockmeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruhr\u2010University Bochum Bochum Germany"},{"name":"Competence Network for HIV\/Aids Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Havenith","sequence":"additional","affiliation":[{"name":"Physical Chemistry II Ruhr\u2010Universit\u00e4t Bochum Bochum 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