{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:42:12Z","timestamp":1774489332309,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The majority of melanoma mutations are <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> transitions, and most bear <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> signatures. However, other process may contribute to the high <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> mutation rate. Okura et\u00a0al<jats:italic>.,<\/jats:italic> have demonstrated immunohistochemical evidence of deaminating enzymes, activation\u2010induced cytidine deaminase (<jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>) and apolipoprotein <jats:styled-content style=\"fixed-case\">B mRNA<\/jats:styled-content>\u2010editing enzyme catalytic polypeptide\u2010like 3B (<jats:styled-content style=\"fixed-case\">APOBEC<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>) in melanoma. Both have been implicated in cancer. While further validation is necessary, these findings warrant consideration of a role for deamination in melanomagenesis. Deamination primarily drives <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> transitions. Compared with trunk\/extremity melanomas, acral melanomas display a significantly higher percentage of \u2018spontaneous\u2019 and \u2018<jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>\u2019 mutation signature events suggesting deamination may be particularly important in this subgroup.<\/jats:p>","DOI":"10.1111\/exd.12436","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T09:46:44Z","timestamp":1399801604000},"page":"551-552","source":"Crossref","is-referenced-by-count":7,"title":["Melanoma's high <scp>C<\/scp>&gt;<scp>T<\/scp> mutation rate: is deamination playing a role?"],"prefix":"10.1111","volume":"23","author":[{"given":"Margaret I.","family":"Sanchez","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"},{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami FL USA"},{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Grichnik","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"},{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami FL USA"},{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-7-11"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12402"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes5010108"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.05.017"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030275"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1562\/2006-02-28-IR-822"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04482"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08658"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.10175"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12436","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:57:04Z","timestamp":1695502624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/exd.12436"],"URL":"https:\/\/doi.org\/10.1111\/exd.12436","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}