{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:55:00Z","timestamp":1774608900330,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 1727\/1"],"award-info":[{"award-number":["GRK 1727\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 306\/2"],"award-info":[{"award-number":["EXC 306\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co\u2010occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> to 4.6% for anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co\u2010occurrence of <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> with specific autoantibodies that target <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CCP<\/jats:styled-content> and Dsg1\/3, while <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content> and autoantibodies to <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180\/<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230 were not more frequent in <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>\u2010positive compared to <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>\u2010negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self\u2010antigens.<\/jats:p>","DOI":"10.1111\/exd.12445","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T09:48:46Z","timestamp":1399801726000},"page":"519-521","source":"Crossref","is-referenced-by-count":29,"title":["Co\u2010occurrence of autoantibodies in healthy blood donors"],"prefix":"10.1111","volume":"23","author":[{"given":"Jasper","family":"Pr\u00fc\u00dfmann","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Pr\u00fc\u00dfmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Recke","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Rentzsch","sequence":"additional","affiliation":[{"name":"Euroimmun Medizinische Labordiagnostika AG L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Juhl","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University Hospital of Schleswig\u2010Holstein L\u00fcbeck and Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Henschler","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine and Immune Hematology German Red Cross Blood Donor Service Baden\u2010W\u00fcrttemberg \u2013 Hessen Clinics of the Goethe University Frankfurt Germany"},{"name":"Transfusion Medicine, Cellular Therapeutics and Hemostaseology Clinics of the Ludwigs\u2010Maximilians\u2010University Munich M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susen","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Vasculitis Center Clinical Center Bad Bramstedt University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck 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