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T cell\u2010mediated autoimmunity explains the progressive nature of this disease. Rather than being confronted with periods of rapid depigmentation and bouts of repigmentation, patients with long\u2010standing, treatment\u2010resistant vitiligo can undergo depigmentation treatment. The objective is to remove residual pigmentation to achieve a cosmetically acceptable result \u2013 that of skin with a uniform appearance. In the United States, only the use of mono\u2010benzyl ether of hydroquinone (<jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content>) is approved for this purpose. However, satisfactory results can take time to appear, and there is a risk of repigmentation. <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content> induces necrotic melanocyte death followed by a cytotoxic T\u2010cell response to remaining, distant melanocytes. As cytotoxic T\u2010cell responses are instrumental to depigmentation, we propose that combining <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content> with immune adjuvant therapies will accelerate immune\u2010mediated melanocyte destruction to achieve faster, more definitive depigmentation than with <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content> alone. As Toll\u2010like Receptor (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>) agonists \u2013 imiquimod, CpG, and Heat Shock Protein 70 (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> 70) \u2013 all support powerful Th1 responses, we propose that using <jats:styled-content style=\"fixed-case\">MBEH<\/jats:styled-content> in combination with these agents can achieve superior depigmentation results for vitiligo patients.<\/jats:p>","DOI":"10.1111\/exd.12449","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T14:42:48Z","timestamp":1400510568000},"page":"529-533","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced bleaching treatment: opportunities for immune\u2010assisted melanocyte suicide in vitiligo"],"prefix":"10.1111","volume":"23","author":[{"given":"Kirsten C.","family":"Webb","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Eby","sequence":"additional","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidhya","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Oncology Research Institute Loyola University Chicago Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie M.","family":"Luiten","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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