{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:16:59Z","timestamp":1790223419810,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P50CA121973-03"],"award-info":[{"award-number":["5P50CA121973-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1 RR024153"],"award-info":[{"award-number":["UL1 RR024153"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunological functions decline with age. Because <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/SzS predominately affects the elderly, it is important to distinguish age\u2010related from cancer\u2010specific changes. Also, <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and SzS are malignancies of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T\u2010lymphocytes, further compromising an immune state of the patients. The objectives of this study were to distinguish disease\u2010specific immunological deterioration by performing comparative age<jats:bold>\u2010<\/jats:bold>matched Luminex multiplex assessment of 34 serum biomarkers between patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>\/SzS, HIV\u2010infected individuals and normal controls. Controlling for age, expression level appears to significantly differ between patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>\/SzS and controls for the following biomarkers: G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20105, <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> VEGF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EOTAXIN<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102R, <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>10, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MIG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TNFR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">TNFR<\/jats:styled-content>2 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), while others showed normal age\u2010related changes. Interestingly, cluster analysis placed <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>\/SzS profiles closer to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>. This further underscores an immunologically compromised state of patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>\/SzS and suggests its potential self\u2010perpetuating role in disease progression.<\/jats:p>","DOI":"10.1111\/exd.12455","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T14:23:03Z","timestamp":1401114183000},"page":"598-600","source":"Crossref","is-referenced-by-count":12,"title":["Distinct age\u2010matched serum biomarker profiles in patients with cutaneous <scp>T<\/scp>\u2010cell lymphoma"],"prefix":"10.1111","volume":"23","author":[{"given":"Larisa J.","family":"Geskin","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"},{"name":"Department of Dermatology Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg E.","family":"Akilov","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Cancer Institute Hillman Cancer Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Lokshin","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Cancer Institute Hillman Cancer Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.7.854"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12363378"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480100060031"},{"key":"e_1_2_3_5_1","first-page":"597","volume":"63","author":"Greene M H","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5526"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1805"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-003-0182-8"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.116345"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00599.x"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90067-5"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02786468"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2879"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-480889"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.06.006"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00263.x"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780242"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.128"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12455","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:57:36Z","timestamp":1695502656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/exd.12455"],"URL":"https:\/\/doi.org\/10.1111\/exd.12455","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]}}}