{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:26:54Z","timestamp":1788870414734,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2010-0021335"],"award-info":[{"award-number":["2010-0021335"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>\n \n Recently, we demonstrated that leucine\u2010rich glioma inactivated 3 (\n LGI<\/jats:styled-content>\n 3) is expressed in human skin. However, the effects of\n LGI<\/jats:styled-content>\n 3 on melanocytes remain unknown. The present study demonstrated that\n LGI<\/jats:styled-content>\n 3 can serve to stimulate melanogenesis without affecting cell viability. To determine the effects of\n LGI<\/jats:styled-content>\n 3 on melanin synthesis, normal human melanocytes and Mel\u2010Ab cells were treated with recombinant\n LGI<\/jats:styled-content>\n 3 and melanin content was measured. Our results showed that\n LGI<\/jats:styled-content>\n 3 promoted melanin synthesis in both cell types. Moreover, upregulation of microphthalmia\u2010associated transcription factor (\n MITF<\/jats:styled-content>\n ) and tyrosinase was observed at both the\n mRNA<\/jats:styled-content>\n and protein levels via\n RT<\/jats:styled-content>\n \u2010\n PCR<\/jats:styled-content>\n and Western blotting, respectively. Furthermore, immunohistochemical staining showed that the expression of\n LG<\/jats:styled-content>\n I3 increased in the basal layer of melasma skin samples, whereas it decreased slightly in vitiligo samples. These results suggest that\n LG<\/jats:styled-content>\n I3 may play a role as a melanogenic cytokine in human skin.\n <\/jats:p>","DOI":"10.1111\/exd.12462","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T03:17:52Z","timestamp":1402024672000},"page":"600-602","source":"Crossref","is-referenced-by-count":15,"title":["Leucine\u2010rich glioma inactivated 3 is a melanogenic cytokine in human skin"],"prefix":"10.1111","volume":"23","author":[{"given":"Hyo\u2010Soon","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Biochemistry Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Mi","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Chung\u2010Ang University College of Medicine Seoul 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