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A correlation between inflammation and cancer has been well established, and anti\u2010inflammatory medications have been shown to be chemopreventive in certain malignancies. Data are now becoming available that outline an inflammatory pathway that may have a critical role in melanomagenesis. <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010regulated membrane channels\/receptors <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>7 and <jats:styled-content style=\"fixed-case\">PANX<\/jats:styled-content>1 have been directly implicated in melanoma tumor growth. Among other potential effects, opening of the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>7\/<jats:styled-content style=\"fixed-case\">PANX<\/jats:styled-content>1 channel results in activation of the <jats:styled-content style=\"fixed-case\">NALP<\/jats:styled-content>3 inflammasome, which in turn leads to caspase\u20101 activation and increased levels of activated <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>. Elevated levels of caspase\u20101 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> have been correlated with melanoma progression, and inhibitors of the inflammasome, caspase and IL\u20101<jats:italic>\u03b2<\/jats:italic> activity have all been shown to inhibit melanoma growth. Among many other potential actions, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> increases cyclooxygenase\u20102 expression leading to local increases in inflammatory mediators such as prostaglandin <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>2 (<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2). Anti\u2010inflammatory medications targeting the end of this pathway have had positive results for certain cancers but overall remain mixed for melanoma. A better understanding of the pathways and appropriate intervention points may help direct future therapies. In this viewpoint, we will review data and attempt to model an inflammatory pathway that may be critical for melanomagenesis and propose future directions for exploration.<\/jats:p>","DOI":"10.1111\/exd.12502","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T15:38:31Z","timestamp":1405525111000},"page":"86-90","source":"Crossref","is-referenced-by-count":35,"title":["Do inflammatory pathways drive melanomagenesis?"],"prefix":"10.1111","volume":"24","author":[{"given":"Samantha L.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami FL USA"},{"name":"Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami FL 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