{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:36:15Z","timestamp":1776436575721,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While the effects of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP have been studied for almost 20\u00a0years, most of these studies have focused on effects on the termination of the anagen phase, giving an incomplete picture of the overall effect of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP on the hair cycle. <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP was determined in several experimental models to promote transition of hair follicles from anagen to catagen phase, which by itself would suggest that <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP blockade might prolong the anagen phase and promote hair growth. However, clinical trials with topically applied <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP antagonists have been disappointing, leading to a reconsideration of this model. Additional studies performed in mouse models where hair follicles are damaged (alopecia areata, chemotherapy\u2010induced alopecia) suggest that <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP has effects early in the hair cycle as well, promoting hair follicles\u2019 entry into anagen phase and initiates the hair cycle. While the mechanism of this has yet to be elucidated, it may involve activation of the Wnt pathway. Thus, the overall effect of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP is to stimulate and accelerate the hair cycle, and in the more clinically relevant models of hair loss where hair follicles have been damaged or become quiescent, it is the agonists, not the antagonists, which would be expected to promote hair growth.<\/jats:p>","DOI":"10.1111\/exd.12504","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T15:39:08Z","timestamp":1405525148000},"page":"865-867","source":"Crossref","is-referenced-by-count":12,"title":["Parathyroid hormone\u2010related peptide and the hair cycle \u2013 is it the agonists or the antagonists that cause hair growth?"],"prefix":"10.1111","volume":"23","author":[{"given":"Robert C.","family":"Gensure","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Children's Hospital at Montefiore and Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.8014"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.3.1133"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12294690"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01410.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12147.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700338"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1442"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-011-9485-1"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27379"},{"key":"e_1_2_4_11_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1242\/dev.128.4.513","volume":"128","author":"Foley J","year":"2001","journal-title":"Development"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1663"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12001"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0544"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00336-1"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.17027"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12286"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507609102"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12024"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700999"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.12.007"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1474"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12009"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2013.25"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01432.x"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3283650bff"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:25:57Z","timestamp":1695536757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/exd.12504"],"URL":"https:\/\/doi.org\/10.1111\/exd.12504","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,25]]}}}