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Impairment of glucocorticoidogenesis through noxious stimuli, such as <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>, can explain pathophysiology of skin diseases (e.g. rosacea). In addition to keratinocytes, melanocytes and fibroblasts, cutaneous adnexes also play a significant role as targets and sources of glucocorticoids, because they express most of the enzymes required for steroidogenesis. Glucocorticoids are also involved in the pathogenesis of acne lesions, affecting sebum production <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Certain steroidogenic enzymes, such as 11<jats:italic>\u03b2<\/jats:italic>\u2010hydroxysteroid dehydrogenase, are upregulated in acne lesions. On this background, the paper by Slominski et\u00a0al. provides further insights into dermatoendocrinology, with emphasis on the importance of an impairment of the skin's own hypothalamic\u2013pituitary\u2013adrenal\u2010like axis in the pathophysiology of several skin diseases.<\/jats:p>","DOI":"10.1111\/exd.12519","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T11:38:25Z","timestamp":1406115505000},"page":"807-808","source":"Crossref","is-referenced-by-count":18,"title":["Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis"],"prefix":"10.1111","volume":"23","author":[{"given":"Georgios","family":"Nikolakis","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos 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