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Thus, we explored in the Mongolian gerbil the effect on scratching behaviour, induced by intra\u2010dermal injection of the<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\u20101 receptor\u2010specific agonist<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>73632, of oral administration of the<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\u20101 receptor antagonist orvepitant. Orvepitant at all doses tested (0.1\u201310\u00a0mg\/kg p.o.) produced a profound inhibition of<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>73632 (30\u00a0nmol i.d.) induced hindlimb scratching; the minimum effective dose of orvepitant in this model was identified as \u22640.1\u00a0mg\/kg. The data generated supported the proposition that the antipruritic potential of orvepitant should be evaluated in clinical trials.<\/jats:p>","DOI":"10.1111\/exd.12528","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T12:53:08Z","timestamp":1406724788000},"page":"858-860","source":"Crossref","is-referenced-by-count":9,"title":["Neurokinin\u20101 receptor antagonist orvepitant is an effective inhibitor of itch\u2010associated response in a<scp>M<\/scp>ongolian gerbil model of scratching behaviour"],"prefix":"10.1111","volume":"23","author":[{"given":"Michael K.","family":"Trower","sequence":"first","affiliation":[{"name":"NeRRe Therapeutics Ltd Stevenage Bioscience Catalyst Stevenage UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Fisher","sequence":"additional","affiliation":[{"name":"Transpharmation Ltd The London Bioscience Innovation Centre London 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