{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:35Z","timestamp":1788871895905,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BMBF"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antimicrobial peptides and proteins (AMP) are highly active molecules with a broad\u2010spectrum of microbicidal activity. Human beta\u2010defensins (\n                    <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>\n                    )\u20102 and\n                    <jats:styled-content style=\"fixed-case\">hBD<\/jats:styled-content>\n                    \u20103 were initially isolated from psoriatic\u2010scale extracts, and other AMP have been identified in high concentrations in psoriatic skin explaining the uncommonness of skin infections in these patients. When a 71\u2010year\u2010old male patient suffering from a mild form of psoriasis (Psoriasis Area Severity Index PASI 4.4) presented a soft tissue infection (erysipelas) surrounding a psoriatic plaque of the elbow, we asked whether a local deficiency of AMP could be the reason for this infection. A detailed analysis of the expression and secretion levels of different classes of AMP was conducted. Induction of AMP was clearly shown by immunohistochemistry as well as by ELISA performed using skin\u2010washing fluids. Therefore, other factors, for example deep penetrating injuries bypassing the keratinocyte innate defense system, must have caused the soft tissue infection.\n                  <\/jats:p>","DOI":"10.1111\/exd.12538","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T12:27:26Z","timestamp":1410611246000},"page":"862-864","source":"Crossref","is-referenced-by-count":6,"title":["Bacterial soft tissue infection in psoriasis despite induction of epidermal antimicrobial peptides"],"prefix":"10.1111","volume":"23","author":[{"given":"Kirsten","family":"Steinz","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schubert","sequence":"additional","affiliation":[{"name":"Institute for Infection Medicine University Hospital Schleswig\u2010Holstein Kiel 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