{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:33:59Z","timestamp":1789720439604,"version":"4.0.1"},"reference-count":9,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is an instructive example highlighting our growing knowledge about pathophysiological functions of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A is the predominant isoform implicated in key pathogenic features in this and other chronic inflammatory disorders. Several monoclonal antibodies targeting <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A (secukinumab, ixekizumab) or its <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> receptor (brodalumab) are currently in late stages of clinical development, where they have shown impressive efficacy. While the eponymous <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 has been thought to originate primarily from T helper (Th)17 cells, more recent investigations by several groups suggest that other cell types in psoriatic lesions, such as neutrophils and mast cells, are rich sources of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, thus presumably contributing to the disease process to an as yet underestimated extent. This recent paradigm shift provides a plausible explanation for the rapid and strong efficacy of the novel compounds targeting <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 functions in psoriasis and other inflammatory disorders, and provide a more comprehensive view on the complex cytokine network in these conditions.<\/jats:p>","DOI":"10.1111\/exd.12541","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T16:27:11Z","timestamp":1410625631000},"page":"804-806","source":"Crossref","is-referenced-by-count":16,"title":["The plot thickens while the scope broadens: a holistic view on <scp>IL<\/scp>\u201017 in psoriasis and other inflammatory disorders"],"prefix":"10.1111","volume":"23","author":[{"given":"Michael P.","family":"Sch\u00f6n","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1551"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12191"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12154"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-345"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109997"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109017"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12487"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2800"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12541","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:19:16Z","timestamp":1695543556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,10]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/exd.12541"],"URL":"https:\/\/doi.org\/10.1111\/exd.12541","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,10]]}}}