{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:35:55Z","timestamp":1791848155011,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polidocanol is a local anaesthetic and antipruritic compound that is used in the treatment of itching skin conditions such as eczema. Its mechanisms of action are largely ill defined. This study has compared the antipruritic efficacy of topical polidocanol in histamine\u2010induced itch and a histamine\u2010independent, cowhage\u2010induced model of pruritus. Polidocanol (3%) or vehicle was applied topically under occlusion for 1\u00a0h to the forearms of 45 healthy volunteers before itch was provoked by rubbing in 40\u201345 spicules of cowhage or skin prick testing with 10\u00a0mg\/ml histamine. Itch was recorded at 1\u2010min intervals for 30\u00a0min on a 100\u2010mm visual analogue scale. Polidocanol significantly reduced the area under the curve for cowhage\u2010induced itch by 58% (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), but had no significant effect on histamine\u2010induced itch. This result underlines the importance of histamine\u2010independent itch models in the development of topical antipruritic agents.<\/jats:p>","DOI":"10.1111\/exd.12555","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T21:17:44Z","timestamp":1412025464000},"page":"922-923","source":"Crossref","is-referenced-by-count":33,"title":["Polidocanol inhibits cowhage \u2010 but not histamine\u2010induced itch in humans"],"prefix":"10.1111","volume":"23","author":[{"given":"Tomasz","family":"Hawro","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim W.","family":"Fluhr","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Skin Research Center Pierre Fabre Dermo Cosmetique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Redoul\u00e8s","sequence":"additional","affiliation":[{"name":"Skin Research Center Pierre Fabre Dermo Cosmetique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-9976","authenticated-orcid":false,"given":"Martin","family":"Metz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1522"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834a41c2"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10217.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0716-08.2008"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00383.x"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1249-07.2007"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1564"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007999709113326"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00329900"},{"key":"e_1_2_2_12_1","first-page":"50","volume":"59","author":"Leopold C S","year":"2004","journal-title":"Pharmazie"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050430"},{"key":"e_1_2_2_14_1","unstructured":"Scientific Committee on Consumer Safety.2011.http:\/\/eceuropaeu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_076."},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017786"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02897.x"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.04.008"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90482.2008"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198012000-00006"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198207000-00003"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12555","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:26:12Z","timestamp":1695536772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/exd.12555"],"URL":"https:\/\/doi.org\/10.1111\/exd.12555","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,25]]}}}