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While\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    is a common inducing factor, other endogenous stresses such as metal ion accumulation or the melanin pigment itself may provide alternative pathways to melanoma progression. Eumelanosomes within melanoma often exhibit disrupted membranes and fragmented pigment which may be due to alterations in their amyloid\u2010based striated matrix. The melanosomal amyloid can itself be toxic, especially in combination with reactive oxygen species (\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    ) and reactive nitrogen species (\n                    <jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content>\n                    ) generated by endogenous\n                    <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\n                    oxidase (\n                    <jats:styled-content style=\"fixed-case\">NOX<\/jats:styled-content>\n                    ) and nitric oxide synthase (\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    ) enzymes, a toxic mix that may initiate melanomagenesis. Further understanding of the loss of the melanosomal organization, the behaviour of the exposed melanin and the induction of\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content>\n                    in melanomas may provide critical insights into this deadly disease.\n                  <\/jats:p>","DOI":"10.1111\/exd.12559","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T06:26:41Z","timestamp":1412144801000},"page":"171-174","source":"Crossref","is-referenced-by-count":21,"title":["Amyloids, melanins and oxidative stress in melanomagenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"Feng","family":"Liu\u2010Smith","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of California School of Medicine Irvine CA USA"},{"name":"Department of Medicine University of 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