{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:44:00Z","timestamp":1775742240673,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n Substantial epidemiological evidence indicates that psoriasis associates with a predisposition to develop metabolic dysregulation leading to obesity and insulin resistance. However, the nature of this association and the potential underlying mechanisms remain unclear. In a recent report, Gerdes\n et\u00a0al<\/jats:italic>\n . explored the hypothesis that wingless\u2010type\n MMTV<\/jats:styled-content>\n integration site, Wnt5a, which has been linked to aberrant fat cell metabolism, may be driving this process. In this study, the authors compare circulating serum levels of Wnt5a in individuals with psoriasis and compare with healthy controls matched for age, gender and\n BMI<\/jats:styled-content>\n . The bottom\u2010line results show higher levels of Wnt5a in psoriasis patients irrespective of\n BMI<\/jats:styled-content>\n compared to the matched non\u2010psoriatic controls, indicating that psoriasis\n per se<\/jats:italic>\n may result in increased secretion of Wnt5a into the circulation. In addition, there was a significant difference among patients with higher levels of Wnt5a in the obese psoriasis population. The study, even though being purely descriptive, may serve to inspire a more mechanistic approach exploring not only Wnt5a, but other inflammatory pathways in between the skin and the fat.\n <\/jats:p>","DOI":"10.1111\/exd.12612","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T18:03:59Z","timestamp":1417543439000},"page":"181-182","source":"Crossref","is-referenced-by-count":3,"title":["Psoriasis: in between the skin and the fat"],"prefix":"10.1111","volume":"24","author":[{"given":"Mona","family":"St\u00e5hle","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Unit Department of Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2012.26"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000062"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12192"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.366"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.103"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12483"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23681.x"},{"key":"e_1_2_3_9_1","first-page":"65","volume":"5","author":"P\u00e9rez\u2010Hern\u00e1ndez A I","year":"2014","journal-title":"Front Endocrinol"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9914-1"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111000565"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.023"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12162"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01210.x"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12413"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1860"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700488"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.280"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12450"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12612","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.12612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:42:16Z","timestamp":1775738536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/exd.12612"],"URL":"https:\/\/doi.org\/10.1111\/exd.12612","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}