{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:44:22Z","timestamp":1775742262370,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Chuo Mitsui Trust and Banking Company, Limited"},{"name":"Grants-in-Aid for Scientific Research","award":["20390308, 20591331, 21659271, 23591634, 23791298, 23791299, 23791300, 23791301, 24659534, 24591672,"],"award-info":[{"award-number":["20390308, 20591331, 21659271, 23591634, 23791298, 23791299, 23791300, 23791301, 24659534, 24591672,"]}]},{"name":"Ishibashi Foundation"},{"name":"Kanae Foundation for the Promotion of Medical Science"},{"name":"Research on Measures for Intractable Diseases\u00ef\u00bf\u00bd\u00ef\u00bf\u00bd\u00ef\u00bf\u00bd\u00ef\u00bf\u00bd Project: matching fund subsidy (H23-028 to K. Iwatsuki, and H24-038 to T. Hashimoto) from the Ministry of Health, Labour and Welfare","award":["H23-028 to K. Iwatsuki, and H24-038 to T. Hashimoto"],"award-info":[{"award-number":["H23-028 to K. Iwatsuki, and H24-038 to T. Hashimoto"]}]},{"name":"Supported Program for the Strategic Research Foundation at Private Universities from the Ministry of Education, Culture, Sports, Science and Technology"},{"name":"Takeda Science Foundation"},{"name":"the Kaibara Morikazu Medical Science Promotion Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this study, we attempted to identify unknown autoantigen for intraepidermal neutrophilic IgA dermatosis\u2010type IgA pemphigus by novel IgA\u2010specific immunoprecipitation. Mass\u2010spectrometry study identified polymeric immunoglobulin receptor (\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    ) as the candidate protein, and we confirmed that\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    expressed in both epidermis and cultured keratinocytes. Eukaryotic recombinant protein of\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    expressed in\n                    <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content>\n                    7 cells was reacted with both patient and normal sera, indicating that\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    binds physiologically to IgA. To detect antigen\u2010specific binding by IgA autoantibodies, we performed several experiments using deglycosylated\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    and F(ab)\n                    <jats:sub>2<\/jats:sub>\n                    fragments from patient sera. However, these analyses suggested that patient IgA bound physiologically, but not immunologically, to\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    . Nevertheless, our study provided two important insights. Newly developed IgA\u2010immunoprecipitation system should be a useful tool in the future study of identification of antigens for IgA autoantibodies. Detection of epidermal\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    in this study confirmed previous results and indicated possible immunological role of\n                    <jats:styled-content style=\"fixed-case\">PIGR<\/jats:styled-content>\n                    in epidermis.\n                  <\/jats:p>","DOI":"10.1111\/exd.12615","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T10:21:13Z","timestamp":1418379673000},"page":"217-219","source":"Crossref","is-referenced-by-count":3,"title":["Epidermal polymeric immunoglobulin receptors: leads from intraepidermal neutrophilic IgA dermatosis\u2010type IgA pemphigus"],"prefix":"10.1111","volume":"24","author":[{"given":"Atsunari","family":"Tsuchisaka","sequence":"first","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwesi","family":"Teye","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Sogame","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Ohata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka 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