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Oxazolone is a well\u2010characterised contact allergen. Previous studies suggested that immune cells bearing the FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    subunit are essential for oxazolone\u2010induced contact hypersensitivity, but the biological functions of the FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    subunit in the process of sensitisation to oxazolone remain unknown. In this study, we show that FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    deficiency decreases ear\u2010swelling responses to oxazolone in mice. However, we found that oxazolone\u2010sensitised FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice and oxazolone\u2010sensitised wild\u2010type (\n                    <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                    ) mice have comparable numbers of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    11c\n                    <jats:sup>+<\/jats:sup>\n                    <jats:styled-content style=\"fixed-case\">MHCII<\/jats:styled-content>\n                    <jats:sup>hi<\/jats:sup>\n                    dendritic cells (\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s) in their draining lymph nodes (\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    s). In addition, oxazolone\u2010sensitised\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    cells from both FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and\n                    <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                    mice showed considerable production of interferon\u2010gamma (\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    <jats:italic>\u03b3<\/jats:italic>\n                    ), interleukin\u20104 (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20104) and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A upon oxazolone\u2010keyhole limpet haemocyanin loading. Consistent with these data, oxazolone\u2010sensitised FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    <jats:sup>+\/+<\/jats:sup>\n                    <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                    cells conferred contact hypersensitivity to\n                    <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                    na\u00efve mice challenged with the hapten. Our findings clearly indicate that, in an experimental mouse model, the FcR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    subunit positively regulates contact hypersensitivity to oxazolone without affecting the contact sensitisation process.\n                  <\/jats:p>","DOI":"10.1111\/exd.12622","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T01:23:02Z","timestamp":1418779382000},"page":"204-208","source":"Crossref","is-referenced-by-count":2,"title":["FcR\n                    <i>\u03b3<\/i>\n                    promotes contact hypersensitivity to oxazolone without affecting the contact sensitisation process in B6 mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Satoshi","family":"Nunomura","sequence":"first","affiliation":[{"name":"Department of Dermatology Nihon University School of Medicine Tokyo Japan"},{"name":"Allergy and Immunology Group Research Institute of Medical Science Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mino","family":"Ohtsubo\u2010Yoshioka","sequence":"additional","affiliation":[{"name":"Momiji Dental Clinic Mejiro Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Okayama","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Group Research Institute of Medical Science Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisei","family":"Ra","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Group Research Institute of Medical Science Nihon University School of Medicine Tokyo Japan"},{"name":"Asahi Hospital Chiba 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