{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:44:21Z","timestamp":1775742261235,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n Ultraviolet radiation (\n UVR<\/jats:styled-content>\n ), in particular the\n UVB<\/jats:styled-content>\n spectrum, is a risk factor for skin cancer development. The generation and accumulation of\n UVB<\/jats:styled-content>\n \u2010induced genetic mutations are fundamental premalignant events. Keratinocyte interactions between other cutaneous cell populations and the surrounding microenvironment determine cell fate and acute photoresponses. In this study, the importance of the insulin\u2010like growth factor (\n IGF<\/jats:styled-content>\n ) system, in particular the insulin\u2010like growth factor\u2010I (\n IGF<\/jats:styled-content>\n \u2010I), on influencing key processes in the keratinocyte acute photoresponse was investigated. Exogenous\n IGF<\/jats:styled-content>\n \u2010I and other growth factors present in dermal fibroblast\u2010conditioned media (\n CM<\/jats:styled-content>\n ) were found to significantly enhance keratinocyte survival following\n UVB<\/jats:styled-content>\n irradiation in vitro. This pretreatment was also shown to cause a shift in the expression levels of various\n DNA<\/jats:styled-content>\n damage response proteins. Consequently, this was associated with accelerated rates of\n UVB<\/jats:styled-content>\n \u2010induced cyclobutane pyrimidine dimer removal in these samples. Finally, activation of the\n IGF<\/jats:styled-content>\n system influenced cell cycle progression in\n UVB<\/jats:styled-content>\n \u2010irradiated keratinocytes. Taken together, these results highlight the importance of the\n IGF<\/jats:styled-content>\n signalling network in initiating the repair of potentially mutagenic\n DNA<\/jats:styled-content>\n damage in human keratinocytes. The dysregulation of these processes may therefore have significant implications in the aetiology of skin cancers and other cutaneous diseases.\n <\/jats:p>","DOI":"10.1111\/exd.12637","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T14:25:05Z","timestamp":1421850305000},"page":"235-238","source":"Crossref","is-referenced-by-count":18,"title":["Insulin\u2010like growth factor\u2010I and\n UVB<\/scp>\n photoprotection in human keratinocytes"],"prefix":"10.1111","volume":"24","author":[{"given":"Tara Lyn","family":"Fernandez","sequence":"first","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek R.","family":"Van Lonkhuyzen","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Kimlin","sequence":"additional","affiliation":[{"name":"AusSun Research Laboratory Institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zee","family":"Upton","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12382494"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06738.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12386"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12317"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01485.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2004.08.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205404"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.440"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12637","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.12637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:42:21Z","timestamp":1775738541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,26]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/exd.12637"],"URL":"https:\/\/doi.org\/10.1111\/exd.12637","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,26]]}}}