{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:45:12Z","timestamp":1791139512872,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CNPq - Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["303621\/2011-7"],"award-info":[{"award-number":["303621\/2011-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is a depigmenting disorder characterized by loss of functional melanocytes from the epidermis. Experimental data suggest that defective melanocyte adhesion may underlie the pathogenesis of the disease. In particular, association between vitiligo and genetic variants of the <jats:italic>DDR1<\/jats:italic> gene involved in melanocyte adhesion has been recently published. A subsequent, independent study revealed lower expression of <jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content>1 in vitiligo lesions. Here, we expand this investigation by testing for association between vitiligo and polymorphisms of <jats:italic>CDH1<\/jats:italic>,<jats:italic> IL1B<\/jats:italic> and <jats:italic>NOV<\/jats:italic> (formerly <jats:italic>CCN3<\/jats:italic>), genes belonging to the <jats:italic>DDR1<\/jats:italic> adhesion pathway, in two population samples of distinct design. Our results reveal that alleles of marker rs10431924 of the <jats:italic>CDH1<\/jats:italic> gene are associated with vitiligo, especially in the presence of autoimmune comorbidities.<\/jats:p>","DOI":"10.1111\/exd.12641","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T15:37:51Z","timestamp":1421941071000},"page":"300-302","source":"Crossref","is-referenced-by-count":27,"title":["Polymorphism of the E\u2010cadherin gene <i><scp>CDH<\/scp>1<\/i> is associated with susceptibility to vitiligo"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-6579","authenticated-orcid":false,"given":"Roberto Gomes","family":"Tarl\u00e9","sequence":"first","affiliation":[{"name":"Department of Dermatology Santa Casa de Miseric\u00f3rdia de Curitiba Hospital Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Cesar","family":"Silva de Castro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Santa Casa de Miseric\u00f3rdia de Curitiba Hospital Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane Machado","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"School of Health and Biosciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo T\u00e1vora","family":"Mira","sequence":"additional","affiliation":[{"name":"Group for Advanced Molecular Investigation Graduate Program in Health Sciences School of Medicine Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba Brazil"},{"name":"School of Health and Biosciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05024.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.34"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12013"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-008-0009-0"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22134"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.175117"},{"issue":"4","key":"e_1_2_2_8_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/jcs.107.4.983","volume":"107","author":"Tang A","year":"1994","journal-title":"J Cell Sci"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8126-5"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107020"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12641","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:43:20Z","timestamp":1695563000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/exd.12641"],"URL":"https:\/\/doi.org\/10.1111\/exd.12641","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}