{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:05:15Z","timestamp":1778547915307,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs) suppress effector <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and ameliorate contact hypersensitivity (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content>); however, the role of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in chronic allergic contact dermatitis (<jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content>) has not been assessed. Repeated elicitation of <jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> has been used to produce <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content> models in mice. We previously showed that the presence of histamine facilitates the creation of eczematous lesions in this model using histidine decarboxylase (<jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content>) (\u2212\/\u2212) mice. Therefore, the effects of histamine on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in the <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content> model were investigated in this study. <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content> was developed by repeated epicutaneous application of 2, 4, 6\u2010trinitro\u20101\u2010chlorobenzene (<jats:styled-content style=\"fixed-case\">TNCB<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content> (+\/+) and <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content> (\u2212\/\u2212) murine skin to assess the effects of histamine in <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content>. Histamine aggravated <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content> in the murine model and suppressed the number of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in the skin. Histamine also suppressed the level of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1 in this model. Recombinant <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1 or anti\u2010<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1 antibody was injected into the dorsal dermis of <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content> (+\/+) mice daily just before <jats:styled-content style=\"fixed-case\">TNCB<\/jats:styled-content> challenge to determine the effects of histamine\u2010regulated <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic> on the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg population in <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content>. Recombinant <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1 injection promoted the infiltration of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in the skin and the production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010; however, anti\u2010<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1 antibody injection suppressed the number of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in the skin and the production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010. Histamine suppresses the number of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs in <jats:styled-content style=\"fixed-case\">CACD<\/jats:styled-content>, and this effect is mediated by <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/exd.12644","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T13:22:42Z","timestamp":1423056162000},"page":"280-284","source":"Crossref","is-referenced-by-count":14,"title":["Histamine suppresses regulatory <scp>T<\/scp> cells mediated by <scp>TGF<\/scp>\u2010<i>\u03b2<\/i> in murine chronic allergic contact dermatitis"],"prefix":"10.1111","volume":"24","author":[{"given":"Kyoko","family":"Tamaka","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition Science Sagami Women's Junior College Bunkyo Minamiku Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Seike","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Science Sagami Women's Junior College Bunkyo Minamiku Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamio","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Science Sagami Women's Junior College Bunkyo Minamiku Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Quantum Science and Energy Engineering Graduate School of Engineering Tohoku University Aramaki Aobaku Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Department of Quantum Science and Energy Engineering Graduate School of Engineering Tohoku University Aramaki Aobaku Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903260"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.4049\/jimmunol.159.5.2484","volume":"159","author":"Kitagaki H","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-005-0569-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00247.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02240.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02854.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01559.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt060"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636207"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939688"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160062"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40926"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02663-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5149"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02621.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06172.x"},{"key":"e_1_2_7_21_1","first-page":"4077","volume":"156","author":"Wang L F","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.11.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200206)32:6<1698::AID-IMMU1698>3.0.CO;2-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324455"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.046"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5760"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051166"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4022"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12644","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:42:44Z","timestamp":1695562964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/exd.12644"],"URL":"https:\/\/doi.org\/10.1111\/exd.12644","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}