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The fact that commonly prescribed <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic>\u2010modulatory drugs of the thiazolidine\u20102,4\u2010dione class can exhibit a battery of adverse cutaneous effects underscores the importance of distinguishing beneficial from clinically undesired cutaneous activities of <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic> ligands and to better understand on the molecular level how <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic>\u2010regulated cutaneous lipid metabolism and <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic>\u2010mediated signalling impact on human skin physiology and pathology. 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