{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:52:24Z","timestamp":1788522744817,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372069"],"award-info":[{"award-number":["81372069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301632"],"award-info":[{"award-number":["81301632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201470"],"award-info":[{"award-number":["81201470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ethanolic extract of Resina Draconis (RDEE) has been reported beneficial to normal wound healing yielding more regularly arranged collagen fibres. Loureirin B, a major component in RDEE, has been supposed to be effective on the prevention and treatment of pathological scars. To investigate the therapeutic effects of loureirin B on hypertrophic scar (HS), fibroblasts from human HS and normal skin (NS) were isolated. Results showed that loureirin B dose\u2010dependently downregulated both m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and protein levels of type I collagen (ColI), type III collagen (ColIII) and <jats:italic>\u03b1<\/jats:italic><jats:bold>\u2010<\/jats:bold>smooth muscle actin (<jats:italic>\u03b1<\/jats:italic><jats:bold>\u2010<\/jats:bold>SMA) in HS fibroblasts. Loureirin B also suppressed fibroblast proliferative activity and redistributed cell cycle, but did not affect cell apoptosis. <jats:italic>In vivo<\/jats:italic> rabbit ear scar model, loureirin B significantly improved the arrangement and deposition of collagen fibres, decreased protein levels of ColI, ColIII and <jats:italic>\u03b1<\/jats:italic><jats:bold>\u2010<\/jats:bold>SMA and suppressed myofibroblast differentiation and scar proliferative activity. In NS fibroblasts, loureirin B effectively inhibited TGF\u2010<jats:italic>\u03b2<\/jats:italic>1\u2010induced upregulation of ColI, ColIII and <jats:italic>\u03b1<\/jats:italic>\u2010SMA levels, myofibroblast differentiation and the activation of Smad2 and Smad3. Loureirin B also affected m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> levels of major MMPs and TIMPs in TGF\u2010<jats:italic>\u03b2<\/jats:italic>1\u2010stimulated fibroblasts. Taken together, this study demonstrates that loureirin B could downregulate the expression of fibrosis\u2010related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF\u2010<jats:italic>\u03b2<\/jats:italic>1\u2010induced fibrosis, during which TGF\u2010<jats:italic>\u03b2<\/jats:italic>1\/Smad2\/3 pathway is likely involved. These findings suggest that loureirin B is a potential therapeutic compound for HS treatment.<\/jats:p>","DOI":"10.1111\/exd.12665","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T07:02:43Z","timestamp":1424070163000},"page":"355-360","source":"Crossref","is-referenced-by-count":72,"title":["Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via <scp>TGF<\/scp>\u2010<i>\u03b2<\/i>\/Smad pathway"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaozhi","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12419"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-013-0195-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-505-7_11"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.055"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700613"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130102.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm809"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070112"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.07.018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/709865"},{"key":"e_1_2_8_13_1","first-page":"276","volume":"17","author":"Li H","year":"2001","journal-title":"Zhonghua Zheng Xing Wai Ke Za Zhi"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199709000-00021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001653107"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.1.103"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01186.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(03)00067-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.035"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.10.052"},{"key":"e_1_2_8_22_1","first-page":"747","volume":"10","author":"Nast A","year":"2012","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.09.009"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-006-0253-y"},{"key":"e_1_2_8_26_1","first-page":"D3826","volume":"9","author":"O'Brien L","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12457"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31824088e3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130211.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00638.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00910.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.101"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00708.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2007.12.007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057474"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0406"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12665","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:03:36Z","timestamp":1696280616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/exd.12665"],"URL":"https:\/\/doi.org\/10.1111\/exd.12665","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}