{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:29:52Z","timestamp":1787563792436,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>\n \n Focal adhesion kinase (\n FAK<\/jats:styled-content>\n ) and Src are non\u2010receptor tyrosine kinases.\n FAK<\/jats:styled-content>\n and Src play a critical role in inducing malignant transformation in tumor cells. We performed immunohistochemical staining for total and phosphorylated forms of\n FAK<\/jats:styled-content>\n and Src, to evaluate the role of\n FAK<\/jats:styled-content>\n and Src in the development of premalignant and malignant skin lesions. A total of 59 facial skin samples (30 actinic keratoses, 10 Bowen's diseases, 13 squamous cell carcinomas and six perilesional skins) were immunohistochemically stained for Ki\u201067, total (t) and phosphorylated (p) form of\n FAK<\/jats:styled-content>\n and Src. Cells positive for t\u2010Src, p\u2010Src\u2010y530, t\u2010\n FAK<\/jats:styled-content>\n and\n pFAK<\/jats:styled-content>\n \u2010s722 were detected in premalignant intra\u2010epithelial lesions (\n PEL<\/jats:styled-content>\n s) and squamous cell carcinomas (\n SCC<\/jats:styled-content>\n s), but not in the perilesional skin. There was a tendency towards high correlation between Ki\u201067 and t\u2010\n FAK<\/jats:styled-content>\n or\n pFAK<\/jats:styled-content>\n \u2010s722, suggestive of the active role of\n FAK<\/jats:styled-content>\n in cell proliferation. However, our findings of higher t\u2010Src and p\u2010Src\u2010y530 positive cells in\n PEL<\/jats:styled-content>\n s, as compared to\n SCC<\/jats:styled-content>\n s (with higher Ki\u201067 level), are suggestive of the other role of Src in tumor formation and progression, which requires further investigation.\n <\/jats:p>","DOI":"10.1111\/exd.12676","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T04:18:43Z","timestamp":1424837923000},"page":"361-364","source":"Crossref","is-referenced-by-count":8,"title":["Focal adhesion kinase and Src expression in premalignant and malignant skin lesions"],"prefix":"10.1111","volume":"24","author":[{"given":"Chong Won","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology Kangbuk Samsung Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kangbuk Samsung Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Pathology Kangbuk Samsung Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Kangbuk Samsung Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Serk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kangbuk Samsung Hospital Seoul 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