{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:19:05Z","timestamp":1778977145477,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Melanocortin 1 receptor (<jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic>) gene variants are a major contributor to pigmentation characteristics and the modulation of sporadic basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) risk. This is a hospital\u2010based, case\u2013control study to investigate the association of <jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic> variants and pigmentary characteristics with the risk of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> development in a Southern European population in Greece. In total, 141 patients with <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> and 166 controls were studied. Increased <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> risk was found for the presence of 2 or more <jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic> variants (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>:3.07, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:1.13\u20138.34), or 2 or more variants of which at least 1 was major function (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>:7.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:1.37\u20135.52), after adjustment for the \u2018red hair colour\u2019 (<jats:styled-content style=\"fixed-case\">RHC<\/jats:styled-content>) phenotype. Increased <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> risk persisted in the presence of 2 or more <jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic> variants (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>:4.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:1.35\u201312.72), after adjustment for potential confounding factors including skin color (<jats:italic>P<\/jats:italic>:0.237) and atypical nevi (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>:9.57, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:2.19\u201341.81, <jats:italic>P<\/jats:italic>:0.003). <jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic> genotype is a risk factor for the development of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> in Greek patients independently of pigmentary characteristics, and the combination of <jats:italic><jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R<\/jats:italic> variants may modulate this risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/exd.12703","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T20:58:25Z","timestamp":1427230705000},"page":"476-478","source":"Crossref","is-referenced-by-count":5,"title":["A case\u2013control study of <i><scp>MC<\/scp>1R<\/i> variants in Greek patients with basal cell carcinoma: increased risk independently of pigmentary characteristics"],"prefix":"10.1111","volume":"24","author":[{"given":"Clio","family":"Dessinioti","sequence":"first","affiliation":[{"name":"Dermato\u2010Oncology Unit 1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vana","family":"Sypsa","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Kypreou","sequence":"additional","affiliation":[{"name":"Dermato\u2010Oncology Unit 1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Dimisianos","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Athens Medical School Agia Sophia Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisavet","family":"Kodela","sequence":"additional","affiliation":[{"name":"Dermato\u2010Oncology Unit 1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Dermato\u2010Oncology Unit 1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Dermato\u2010Oncology Unit 1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Stratigos","sequence":"additional","affiliation":[{"name":"Dermato\u2010Oncology Unit 1st Department of Dermatology University of Athens Andreas Sygros Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2010.00735.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12540"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.00970.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.132"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/319500"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700263"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.402"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23257"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.010"}],"container-title":["Experimental 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