{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:09:13Z","timestamp":1780628953018,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Austrian Science Fund, Vienna, Austria","award":["DK-W1212"],"award-info":[{"award-number":["DK-W1212"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemokines are small chemotactic proteins that have a crucial role in leukocyte recruitment into tissue. Targeting these mediators has been suggested as a potential therapeutic option in inflammatory skin diseases such as psoriasis. Using quantitative <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, we found <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>7, a chemokine ligand known to interact with multiple C\u2010C chemokine receptors, to be markedly increased in lesional psoriasis as opposed to atopic dermatitis, lichen planus, non\u2010lesional psoriatic and normal control skin. Surprisingly, this increase in <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>7 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression exceeded that of all other chemokines investigated, and keratinocytes and dermal blood endothelial cells were identified as its likely cellular sources. In an imiquimod\u2010induced psoriasis\u2010like mouse model, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>7 had a profound impact on myeloid cell inflammation as well as on the upregulation of key pro\u2010psoriatic cytokines such as <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012p40 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017C, while its blockade led to an increase in the antipsoriatic cytokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104. In humans receiving the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010blocker infliximab, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>7 was downregulated in lesional psoriatic skin already within 16\u00a0hours after a single intravenous infusion. These data suggest that <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>7 acts as a driver of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010dependent Th1\/Th17\u2010mediated inflammation in lesional psoriatic skin.<\/jats:p>","DOI":"10.1111\/exd.12709","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T18:21:49Z","timestamp":1427912509000},"page":"522-528","source":"Crossref","is-referenced-by-count":39,"title":["<scp>CCL<\/scp>7 contributes to the <scp>TNF<\/scp>\u2010alpha\u2010dependent inflammation of lesional psoriatic skin"],"prefix":"10.1111","volume":"24","author":[{"given":"Patrick M.","family":"Brunner","sequence":"first","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Glitzner","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research Department of Medicine I Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baerbel","family":"Reininger","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Stary","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mildner","sequence":"additional","affiliation":[{"name":"Research Division of Biology and Pathobiology of the Skin Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Uhrin","sequence":"additional","affiliation":[{"name":"Department of Vascular Biology and Thrombosis Research Center for Physiology and Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sibilia","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research Department of Medicine I Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00832.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12469"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109997"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10583.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3646"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005074"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.06.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.08.049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.36"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.12.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052242"},{"key":"e_1_2_9_18_1","first-page":"554","volume":"12","author":"Menten P","year":"2001","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100277"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-514372"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61862"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404114"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.11.003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.054"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01323.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.59"},{"key":"e_1_2_9_29_1","first-page":"271","volume":"8","author":"Polentarutti N","year":"1997","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0242"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<678::AID-IMMU678>3.0.CO;2-J"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400782101"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-11-r130"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1995.0065"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29919"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900604"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3284"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12163"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1210.10057"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12847"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.036"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052723"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103053"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509736102"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.165"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.10.6846"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.33"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201505"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.65"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810652"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050500"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.042"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm804"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901316"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12709","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:02:26Z","timestamp":1695571346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/exd.12709"],"URL":"https:\/\/doi.org\/10.1111\/exd.12709","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]}}}