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We examined the clinical and immunological response patterns of 100 subjects with moderate\u2010to\u2010severe psoriasis receiving 3 different intravenous dosing regimens of the anti\u2010\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A antibody secukinumab (1\u00a0\u00d7\u00a03\u00a0mg\/kg or 1\u00a0\u00d7\u00a010\u00a0mg\/kg on Day 1, or 3\u00a0\u00d7\u00a010\u00a0mg\/kg on Days 1, 15 and 29) or placebo in a phase 2 trial. Baseline biopsies revealed typical features of active psoriasis, including epidermal accumulation of neutrophils and formation of microabscesses in &gt;60% of cases. Neutrophils were the numerically largest fraction of infiltrating cells containing\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 and may store the cytokine preformed, as\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    was not detectable in neutrophils isolated from active plaques. Significant clinical responses to secukinumab were observed 2\u00a0weeks after a single infusion, associated with extensive clearance of cutaneous neutrophils parallel to the normalization of keratinocyte abnormalities and reduction of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017\u2010inducible neutrophil chemoattractants (e.g.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\n                      8\n                    <\/jats:italic>\n                    ); effects on numbers of T cells and\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    11c\u2010positive dendritic cells were more delayed. Histological and immunological improvements were generally dose dependent and not observed in the placebo group. In the lowest\u2010dose group, a recurrence of neutrophils was seen in some subjects at Week 12; these subjects relapsed faster than those without microabscesses. Our findings are indicative of a neutrophil\u2013keratinocyte axis in psoriasis that may involve neutrophil\u2010derived\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 and is an early target of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A\u2010directed therapies such as secukinumab.\n                  <\/jats:p>","DOI":"10.1111\/exd.12710","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T16:55:49Z","timestamp":1427993749000},"page":"529-535","source":"Crossref","is-referenced-by-count":193,"title":["Evidence that a neutrophil\u2013keratinocyte crosstalk is an early target of\n                    <scp>IL<\/scp>\n                    \u201017A inhibition in psoriasis"],"prefix":"10.1111","volume":"24","author":[{"given":"Kristian","family":"Reich","sequence":"first","affiliation":[{"name":"Dermatologikum Hamburg and SCIderm Research Institute Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Papp","sequence":"additional","affiliation":[{"name":"Probity Medical Research Inc Waterloo ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Matheson","sequence":"additional","affiliation":[{"name":"Oregon Medical Research Center PC Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Tu","sequence":"additional","affiliation":[{"name":"Skin Search of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bissonnette","sequence":"additional","affiliation":[{"name":"Innovaderm Research Inc Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Moncton NB 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