{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:18:36Z","timestamp":1789172316972,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the 1980s, Streilein et\u00a0al. introduced the term \u2018skinassociated lymphoid tissue (<jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content>)\u2019 based on observations that revealed the existence of T cells and dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s) in the skin and that T cells are activated in the skin draining lymph nodes. However, in the perspective of <jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content>, it remains still unclear whether and how cellular components in the skin interact with each other. In addition, whether the T\u2010cell activation occurs in the skin in\u00a0situ has also been unrevealed. With the close observation of a skin specimen obtained from a patient with contact dermatitis, we discovered that dermal <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">dDC<\/jats:styled-content>s) clustered and closely attached to T cells. Thus, we hypothesized that this clustering might be essential for the establishment of the dermatitis and the T\u2010cell activation in\u00a0situ. Through the detailed examination of the elicitation phase of contact hypersensitivity as a murine model of contact dermatitis, we demonstrated the formation of sequential leukocyte clusters at the postcapillary venules. The clusters include perivascular macrophages that are activated by <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101a produced by keratinocytes and <jats:styled-content style=\"fixed-case\">dDC<\/jats:styled-content>s that are attracted by these macrophages through <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>2 signalling, both of which are essential for the efficient activation of memory T cells in\u00a0situ. The structure does not exist in the steady state, but is \u2018induced\u2019 in response to local inflammatory conditions. Herein, we propose that this structure to be termed as \u2018inducible <jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">iSALT<\/jats:styled-content>)\u2019.<\/jats:p>","DOI":"10.1111\/exd.12716","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T15:33:03Z","timestamp":1428766383000},"page":"630-631","source":"Crossref","is-referenced-by-count":24,"title":["Proposal of inducible skin\u2010associated lymphoid tissue (<scp>iSALT<\/scp>)"],"prefix":"10.1111","volume":"24","author":[{"given":"Sachiko","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12521270"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"12s","DOI":"10.1111\/1523-1747.ep12536743","volume":"80","author":"Streilein J W","year":"1983","journal-title":"J Invest Dermatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11190.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.198"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2992"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2769"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1091"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12716","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:09:59Z","timestamp":1695503399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/exd.12716"],"URL":"https:\/\/doi.org\/10.1111\/exd.12716","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}