{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:52:56Z","timestamp":1790553176382,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The erythroid differentiation regulator 1 (Erdr1), which is a novel and highly conserved factor, was recently reported to be negatively regulated by <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 and to play a crucial role as an antimetastatic factor. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 is a proinflammatory cytokine that functions as an angiogenic mediator in inflammation. Rosacea is a chronic inflammatory skin disorder that is characterized by abnormal inflammation and vascular hyperactivity of the facial skin. To determine whether Erdr1 contributes to the regulation of the chronic inflammatory process in the development of rosacea, an immunohistochemical analysis was performed in healthy donors and patients with rosacea. In this study, we showed that Erdr1 was downregulated, whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 was upregulated, in patients with rosacea, which led us to question the role of Erdr1 in this disorder. Moreover, a rosacea\u2010like <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mouse model was used to determine the role of Erdr1 in rosacea <jats:italic>in\u00a0vivo<\/jats:italic>. <jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content>\u201037 injection induced typical rosacea features, including erythema, telangiectasia and inflammation. Treatment with recombinant Erdr1 (r<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>rdr1) resulted in a significant reduction of erythema, inflammatory cell infiltration (including <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells), and microvessel density with vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>). Taken together, our findings suggest that r<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>rdr1 may be involved in attenuating the inflammation and angiogenesis associated with the pathogenesis of rosacea. Thus, these results provide new insight into the mechanism involved in this condition and indicate that r<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>rdr1 could be a potential target for therapeutic intervention of rosacea.<\/jats:p>","DOI":"10.1111\/exd.12745","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T14:07:04Z","timestamp":1430575624000},"page":"680-685","source":"Crossref","is-referenced-by-count":62,"title":["Recombinant erythroid differentiation regulator 1 inhibits both inflammation and angiogenesis in a mouse model of rosacea"],"prefix":"10.1111","volume":"24","author":[{"given":"Miri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science Sookmyung Women's University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haw Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunmu","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo\u2010won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Mercersburg Academy Mercesburg PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Biotech. 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