{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:50Z","timestamp":1792787030496,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science"},{"name":"ICT"},{"name":"Future Planning","award":["NRF-2014R1A2A2A01006882"],"award-info":[{"award-number":["NRF-2014R1A2A2A01006882"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasma, freckles, age spots and chloasma. The aim of this study was to investigate the antimelanogenic effect of sesamol, an active lignan isolated from\n                    <jats:italic>Sesamum indicum<\/jats:italic>\n                    , in melan\u2010a cells. Sesamol strongly inhibited melanin biosynthesis and the activity of intracellular tyrosinase by decreasing cyclic adenosine monophosphate (\n                    <jats:styled-content style=\"fixed-case\">cAMP<\/jats:styled-content>\n                    ) accumulation. Sesamol significantly decreased the expression of melanogenesis\u2010related genes, such as tyrosinase, tyrosinase\u2010related protein\u20101,2 (\n                    <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>\n                    \u20101,2), microphthalmia\u2010associated transcription factor (\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    ) and melanocortin 1 receptor (\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    1R). In addition, sesamol also induces phosphorylation of p38 mitogen\u2010activated protein kinase (p38\n                    <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>\n                    ) and c\u2010Jun N\u2010terminal kinase (\n                    <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n                    ). Moreover, sesamol dose\u2010dependently decreased zebrafish pigment formation, tyrosinase activity and expression of melanogenesis\u2010related genes. These findings indicate that sesamol inhibited melanin biosynthesis by down\u2010regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis\u2010related proteins through modulation of\n                    <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\n                    activity, which promoted phosphorylation of p38 and\n                    <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n                    in melan\u2010a cells. Together, these results suggest that sesamol strongly inhibits melanin biosynthesis, and therefore, sesamol represents a new skin\u2010whitening agent for use in cosmetics.\n                  <\/jats:p>","DOI":"10.1111\/exd.12765","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T04:03:33Z","timestamp":1432353813000},"page":"761-766","source":"Crossref","is-referenced-by-count":77,"title":["Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of\n                    <scp>MITF<\/scp>\n                    via the intracellular\n                    <scp>cAMP<\/scp>\n                    and p38\/\n                    <scp>JNK<\/scp>\n                    signalling pathways"],"prefix":"10.1111","volume":"24","author":[{"given":"Seung\u2010hwa","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Food Science &amp; Biotechnology Graduate School Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Biotechnology Graduate School Kyungpook National University Daegu Korea"},{"name":"Department of Nano\u2010Science &amp; Technology Graduate School Kyungpook National University Daegu Korea"},{"name":"Food &amp; Bio\u2010industry Research Institute Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00013-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1038\/skinbio.2011.4","volume":"17","author":"Hearing V J","year":"2011","journal-title":"J Invest 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