{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:57:07Z","timestamp":1790251027586,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","award":["KTP008918"],"award-info":[{"award-number":["KTP008918"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing evidence has identified ultraviolet radiation (<jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>) as the skins most potent mutagen as over exposure results in sunburn, inflammation and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, thus contributing to a photo\u2010ageing phenotype and possibly skin carcinogenesis. The lipid\u2010rich sebum secreted onto the surface of the skin plays an important physiological role in protecting the skin against external challenges. When skin is photosensitised by <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>, the lipid constituents of sebum are easily oxidised, generating several lipid photo\u2010oxidative products (e.g. squalene peroxides). These photo\u2010oxidative products have been shown to exert diverse toxicological, biological and immunological effects in the skin and have therefore been implicated in several detrimental skin alterations including premature skin ageing. The involvement of lipid peroxidation products in <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\u2010induced inflammatory responses has been inadequately studied and highly controversial. Furthermore, it is unclear to what extent these oxidative products contribute to the underlying mechanisms of skin photo\u2010ageing. Therefore, this viewpoint essay will discuss the current knowledge on the effect of <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> exposure on skin surface lipids and how these may mediate <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\u2010induced inflammatory responses which may be key contributors to photo\u2010damage in skin. This essay will also examine the potential role of inflammasomes (innate immune\u00a0complexes) in the inflammatory response associated with <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\u2010induced lipid peroxidation. Limited evidence is available on the interactions between sebaceous lipids, downstream mediators and concomitant immune response in sun\u2010exposed skin and clearer elucidation may lead to novel biomarkers of photo\u2010ageing and the incorporation of new molecules into current skin therapies which better target oxidised lipids and or downstream mediators\/pathways.<\/jats:p>","DOI":"10.1111\/exd.12774","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:06:38Z","timestamp":1432735598000},"page":"651-654","source":"Crossref","is-referenced-by-count":30,"title":["Sebum, inflammasomes and the skin: current concepts and future perspective"],"prefix":"10.1111","volume":"24","author":[{"given":"Anne O.","family":"Oyewole","sequence":"first","affiliation":[{"name":"Dermatological Sciences Institute of Cellular Medicine Newcastle University Newcastle upon Tyne NE2 4HH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Birch\u2010Machin","sequence":"additional","affiliation":[{"name":"Dermatological Sciences Institute of Cellular Medicine Newcastle University Newcastle upon Tyne NE2 4HH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D008391"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12465246"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000060651"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00794.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760290021342"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12532792"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0879-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0369-8114(03)00074-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12431"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/858176"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-319-09943-9_12","volume-title":"Lipids 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