{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:21Z","timestamp":1790520381217,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>\n \n Conflicting observations have been reported concerning the role of\n CD<\/jats:styled-content>\n 1d\u2010dependent natural killer T (\n NKT<\/jats:styled-content>\n ) cells in contact hypersensitivity (\n CHS<\/jats:styled-content>\n ), supporting either a disease\u2010promoting or downregulatory function. We studied the role of\n NKT<\/jats:styled-content>\n cells in\n CHS<\/jats:styled-content>\n by comparing the immune response in\n CD<\/jats:styled-content>\n 1d knockout (\n CD<\/jats:styled-content>\n 1d\n KO<\/jats:styled-content>\n ) and wild\u2010type (Wt) mice after contact allergen exposure. For induction of\n CHS<\/jats:styled-content>\n , C57\n BL<\/jats:styled-content>\n \/6\n CD<\/jats:styled-content>\n 1d\n KO<\/jats:styled-content>\n mice (\n n<\/jats:italic>\n \u00a0=\u00a06) and C57\n BL<\/jats:styled-content>\n \/6 Wt mice (\n n<\/jats:italic>\n \u00a0=\u00a06) were sensitised with 1% (w\/v) dinitrochlorobenzene (\n DNCB<\/jats:styled-content>\n ) or vehicle for three consecutive days and subsequently challenged with a single dose of 0.5%\n DNCB<\/jats:styled-content>\n (w\/v) on the ears fifteen days later. We demonstrate that\n CD<\/jats:styled-content>\n 1d\n KO<\/jats:styled-content>\n mice, as compared with Wt littermates, have more pronounced infiltration of mononuclear cells in the skin (29.1% increase;\n P<\/jats:italic>\n \u00a0<\u00a00.001), lower frequencies of interleukin\u201010\n +<\/jats:sup>\n B cells (B\n regs<\/jats:sub>\n ) in the spleen (53.2% decrease;\n P<\/jats:italic>\n \u00a0<\u00a00.05) and peritoneal cavity (80.8% decrease;\n P<\/jats:italic>\n \u00a0<\u00a00.05) and increased production of interferon\u2010\n \u03b3<\/jats:italic>\n (3\u2010fold;\n P<\/jats:italic>\n \u00a0<\u00a00.05) after\n DNCB<\/jats:styled-content>\n sensitisation and challenge, which suggests an important regulatory and protective role of\n CD<\/jats:styled-content>\n 1d\u2010dependent\n NKT<\/jats:styled-content>\n cells in\n CHS<\/jats:styled-content>\n in our model, at least in part via regulation of\n IL<\/jats:styled-content>\n \u201010 producing B\n regs<\/jats:sub>\n .\n <\/jats:p>","DOI":"10.1111\/exd.12792","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T06:51:48Z","timestamp":1435560708000},"page":"853-856","source":"Crossref","is-referenced-by-count":14,"title":["CD<\/scp>\n 1d knockout mice exhibit aggravated contact hypersensitivity responses due to reduced interleukin\u201010 production predominantly by regulatory B cells"],"prefix":"10.1111","volume":"24","author":[{"given":"Jonas","family":"Fjelbye","sequence":"first","affiliation":[{"name":"The Bartholin Institute Rigshospitalet Copenhagen Biocenter Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Antvorskov","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet Copenhagen Biocenter Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Buschard","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet Copenhagen Biocenter Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Issazadeh\u2010Navikas","sequence":"additional","affiliation":[{"name":"Neuroinflammation Unit Biotech Research and Innovation Centre (BRIC) University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re","family":"Engkilde","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet Copenhagen Biocenter Copenhagen Denmark"},{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre Gentofte Hospital University of Copenhagen Copenhagen 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