{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:39:41Z","timestamp":1792539581061,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is a chronic inflammatory disabling skin disease consisting of recurrent nodules, sinuses, fistulas and scarring involving the intertriginous regions. <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> is often a therapeutic challenge and most treatments are off\u2010label. A better understanding of aetiology and pathogenesis of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> may facilitate the development of effective treatment. Although the clinical presentation is strongly reminiscent of bacterial infection, the role of bacteria remains controversial. Studies have isolated an array of different bacteria specimens. Consistent findings of Gram\u2010positive cocci and Gram\u2010positive rods including <jats:italic>Staphylococus aureus<\/jats:italic>, coagulase\u2010negative staphylococci (Co<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) and <jats:italic>Corynebacterium<\/jats:italic> species in deep tissue samples have been demonstrated in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and may constitute a central target for the immune system. Efficacy of antibiotics, that is rifampicin, clindamycin or tetracycline, supports a microbial role in disease pathogenesis. However, these antibiotics also work as immunomodulators of especially T cells, and the underlying mechanisms may therefore be more complex. We performed a systematic review of previous studies investigating the bacterial flora in hidradenitis suppurativa. We searched PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, Royal Danish Library and Cochrane library (search date 11 December 2014). A total of 66 papers were identified and nine papers published between 1988 and 2014 matched our inclusion criteria, yielding bacteriological data of a total of 324 patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> (mean age 36.8\u00a0years and female\/male ratio 215\/109). This overview of the bacteriology may aid researchers and physicians exploring the potential role of bacteria in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. Furthermore, to stimulate a broader debate, we also present different viewpoints on the possible role of bacteria in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.12793","type":"journal-article","created":{"date-parts":[[2015,6,28]],"date-time":"2015-06-28T07:03:05Z","timestamp":1435474985000},"page":"727-731","source":"Crossref","is-referenced-by-count":91,"title":["The bacteriology of hidradenitis suppurativa: a systematic review"],"prefix":"10.1111","volume":"24","author":[{"given":"Hans Christian","family":"Ring","sequence":"first","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Riis Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iben Marie","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard","family":"Jenssen","sequence":"additional","affiliation":[{"name":"Department of Science, Systems and Models Roskilde University Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Fuursted","sequence":"additional","affiliation":[{"name":"Department of bacteriology Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte Marie","family":"Saunte","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B.E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90321-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13090"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.1165"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031810"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10224.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00915.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10254.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07556.x"},{"key":"e_1_2_7_14_1","first-page":"1","volume":"19","author":"Scheinfeld N","year":"2013","journal-title":"Dermatol Online J"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-12-201212180-00004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2011.571657"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2012.140064"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246246"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02613.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10747.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228334"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228337"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1841"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01552.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096194"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-48-1-103"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709789352321"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1841"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00712_1.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1996"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-1-31"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00204.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.075549.107"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00438-3"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1128\/jcm.30.2.261-264.1992","volume":"30","author":"Kamath U","year":"1992","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.49.100195.003431"},{"key":"e_1_2_7_38_1","first-page":"Doc23","volume":"9","author":"Namvar A E","year":"2014","journal-title":"GMS Hyg Infect Control"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.56"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12220"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2012.00946.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm378"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12787"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0087"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00003-14"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801307010146"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12030"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70349-4"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670070035015"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670070031014"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12793","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:29:25Z","timestamp":1695536965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,21]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/exd.12793"],"URL":"https:\/\/doi.org\/10.1111\/exd.12793","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,21]]}}}