{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:54:57Z","timestamp":1790553297741,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hungarian National Research Fund","award":["OTKA NN117020"],"award-info":[{"award-number":["OTKA NN117020"]}]},{"name":"Marie Sk\u0142odowska-Curie Actions","award":["627547"],"award-info":[{"award-number":["627547"]}]},{"name":"RNAsebgland","award":["FP7-PEOPLE-2013-IEF"],"award-info":[{"award-number":["FP7-PEOPLE-2013-IEF"]}]},{"name":"Lend\u00fclet","award":["LP2011-003\/2015"],"award-info":[{"award-number":["LP2011-003\/2015"]}]},{"name":"IGEN Hungarian","award":["T\u00c1MOP-4.2.2.A-11\/1\/KONV-2012-0031"],"award-info":[{"award-number":["T\u00c1MOP-4.2.2.A-11\/1\/KONV-2012-0031"]}]},{"name":"European Union and the European Social Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In addition to producing sebum, sebocytes link lipid metabolism with inflammation at a cellular level and hence, greatly resemble adipocytes. However, so far no analysis was performed to identify and characterize the adipocyte\u2010associated inflammatory proteins, the members of the adipokine family in sebocytes. Therefore, we determined the expression profile of adipokines [adiponectin, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>) 6, resistin, leptin, serpin E1, visfatin, apelin, chemerin, retinol\u2010binding protein 4 (<jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4) and monocyte chemoattractant protein 1 (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1)] in sebaceous glands of healthy and various disease\u2010affected (acne, rosacea, melanoma and psoriasis) skin samples. Sebaceous glands in all examined samples expressed adiponectin, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6, resistin, leptin, serpin E1 and visfatin, but not apelin, chemerin, <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1. Confirming the presence of the detected adipokines in the human <jats:styled-content style=\"fixed-case\">SZ<\/jats:styled-content>95 sebaceous gland cell line we further characterized their expression and secretion patterns under different stimuli mimicking bacterial invasion [by using Toll\u2010like receptor (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>)2 and 4 activators], or by 13\u2010<jats:italic>cis<\/jats:italic> retinoic acid (13<jats:styled-content style=\"fixed-case\">CRA<\/jats:styled-content>; also known as isotretinoin), a key anti\u2010acne agent. With the exception of resistin, the expression of all of the detected adipokines (adiponectin, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6, leptin, serpin E1 and visfatin) could be further regulated at the level of gene expression, showing a close correlation with the secreted protein levels. Besides providing further evidence on similarities between adipocytes and sebocytes, our results strongly suggest that sebocytes are not simply targets of inflammation but may exhibit initiatory and modulatory roles in the inflammatory processes of the skin through the expression and secretion of adipokines.<\/jats:p>","DOI":"10.1111\/exd.12879","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T15:18:42Z","timestamp":1445095122000},"page":"194-199","source":"Crossref","is-referenced-by-count":65,"title":["Sebocytes differentially express and secrete adipokines"],"prefix":"10.1111","volume":"25","author":[{"given":"D\u00f3ra","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Debrecen Debrecen Hungary"},{"name":"MTA\u2010DE Public Health Research group of the Hungarian Academy of Sciences Faculty of Public Health University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Lov\u00e1szi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szil\u00e1rd","family":"P\u00f3liska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Genomic Medicine and Bioinformatics Core Facility Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-5639","authenticated-orcid":false,"given":"Attila","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"DE\u2010MTA \u201cLend\u00fclet\u201d Cellular Physiology Research Group Department of Physiology University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"B\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"DE\u2010MTA \u201cLend\u00fclet\u201d Cellular Physiology Research Group Department of Physiology University of Debrecen Debrecen Hungary"},{"name":"Department of Immunology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Veres","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"St\u00e5hle","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Venereology Department of Medicine Karolinska lnstitutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"R\u00fchl","sequence":"additional","affiliation":[{"name":"MTA\u2010DE Public Health Research group of the Hungarian Academy of Sciences Faculty of Public Health University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Remenyik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"T\u00f6r\u0151csik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Debrecen Debrecen Hungary"},{"name":"Unit of Dermatology and Venereology Department of Medicine Karolinska lnstitutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00725.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/858176"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.04.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700743"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00612.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12411.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12647"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041213"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01210.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/760691"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009000600005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00771.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199106000-00003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2010.528566"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017861"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0715-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12512506"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.2.383"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12263.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.07.031"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00332"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0068fje"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058709"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1994.tb00052.x"},{"key":"e_1_2_8_27_1","first-page":"731","volume":"59","author":"Krskova\u2010Tybitanclova K","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1350"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1683"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112826"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13229"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9148"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.018"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1677"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12142"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1201"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.665893"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.044"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-427708"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01541.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22783"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01523.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.08.145"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.06.004"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101739"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.217"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12879","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:20:23Z","timestamp":1695514823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/exd.12879"],"URL":"https:\/\/doi.org\/10.1111\/exd.12879","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}