{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:51:47Z","timestamp":1790373107748,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 1602\/7\u20103"],"award-info":[{"award-number":["HE 1602\/7\u20103"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pemphigus vulgaris (PV) is a potentially life\u2010threatening autoimmune disease of the skin and mucous membranes. Its pathogenesis is based on IgG autoantibodies that target the desmosomal cadherins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1) and induce intra\u2010epidermal loss of adhesion. Although the PV pathogenesis is well\u2010understood, therapeutic options are still limited to immunosuppressive drugs, particularly corticosteroids, which are associated with significant side effects. Dsg3\u2010reactive T regulatory cells (Treg) have been previously identified in PV and healthy carriers of PV\u2010associated HLA class II alleles. <jats:italic>Ex vivo<\/jats:italic>, Dsg3\u2010specific Treg cells down\u2010regulated the activation of pathogenic Dsg3\u2010specific T\u2010helper (Th) 2 cells. In this study, in a HLA\u2010DRB1*04:02 transgenic mouse model of PV, peripheral Treg cells were modulated by the use of Treg\u2010depleting or expanding monoclonal antibodies, respectively. Our findings show that, <jats:italic>in vivo<\/jats:italic>, although not statistically significant, Treg cells exert a clear down\u2010regulatory effect on the Dsg3\u2010driven T\u2010cell response and, accordingly, the formation of Dsg3\u2010specific IgG antibodies. These observations confirm the powerful immune regulatory functions of Treg cells and identify Treg cells as potential therapeutic modulators in PV.<\/jats:p>","DOI":"10.1111\/exd.12919","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T13:18:27Z","timestamp":1450099107000},"page":"293-298","source":"Crossref","is-referenced-by-count":30,"title":["Induction of <scp>T<\/scp> regulatory cells by the superagonistic anti\u2010<scp>CD<\/scp>28 antibody <scp>D<\/scp>665 leads to decreased pathogenic <scp>I<\/scp>g<scp>G<\/scp> autoantibodies against desmoglein 3 in a <scp>HLA<\/scp>\u2010transgenic mouse model of pemphigus vulgaris"],"prefix":"10.1111","volume":"25","author":[{"given":"Thomas","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology Philipps\u2010University Marburg Marburg 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