{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:10:32Z","timestamp":1774008632506,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Trichophyton<\/jats:italic> infection is highly prevalent and tends to be recurrent. Therefore, it is important to develop new therapeutic agents. Previously, we established a mouse model of <jats:italic>Trichophyton<\/jats:italic>\u2010induced contact hypersensitivity (<jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content>) and demonstrated that dectin\u20101 was involved in inflammation induced by trichophytin, the <jats:italic>Trichophyton<\/jats:italic> antigen. Here, we used that model to investigate glycyrrhetinic acid (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) from plants of the genus <jats:italic>Glycyrrhiza<\/jats:italic> as a potential anti\u2010inflammatory agent against superficial mycoses. <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> suppressed swelling and the expression of inflammatory cytokines, including macrophage inflammatory protein (<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>)\u20102, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20106, tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010<jats:italic>\u03b1<\/jats:italic> and interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>)\u2010<jats:italic>\u03b3 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>. Anti\u2010<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20102 antibody suppressed trichophytin\u2010induced inflammation, and antidectin\u20101 antibody suppressed zymosan\u2010induced <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20102 production in keratinocyte cells. These results suggest that <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20102 is produced by dectin\u20101 activation and is involved in inflammation associated with <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> to trichophytin. <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> also suppressed zymosan\u2010induced <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20102 and interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20108, production in mouse and human macrophages and keratinocytes. Furthermore, <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> suppressed the phosphorylation of spleen tyrosine kinase (Syk) and inhibitor of nuclear factor\u2010kappa B (I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic>) and the degradation of I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic> in zymosan\u2010simulated <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells. The results of this study suggest that <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> suppresses inflammation induced by trichophytin, partly by the downregulation of Syk phosphorylation.<\/jats:p>","DOI":"10.1111\/exd.12931","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T12:18:50Z","timestamp":1452169130000},"page":"299-304","source":"Crossref","is-referenced-by-count":18,"title":["Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin\u20101"],"prefix":"10.1111","volume":"25","author":[{"given":"Tomoya","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of R&amp;D Center Ikeda Mohando Co., Ltd Toyama Japan"},{"name":"Department of Dermatology Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Nishibu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Center Ikeda Mohando Co., Ltd Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsue","family":"Yasoshima","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Center Ikeda Mohando Co., Ltd Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Anzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Science for Research University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Science for Research University of Toyama Toyama Japan"},{"name":"Japan Science and Technology Agency Precursory Research for Embryonic Science and Technology Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Science for Research University of Toyama Toyama Japan"},{"name":"Toyama Prefectural Institute for Pharmaceutical Research Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Center Ikeda Mohando Co., Ltd Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.10.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1140"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.02.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1745"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1999.00858.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3876"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132349"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2011.58"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101111200"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2340\/0001555576399400","volume":"76","author":"Koga T","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(02)00136-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08897.x"},{"key":"e_1_2_8_14_1","first-page":"935","volume":"9","author":"Nakamura Y","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80137-X"},{"key":"e_1_2_8_16_1","first-page":"2095","volume":"65","author":"Weinstein A","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/338023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/767589"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.120.10_849"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb11801.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/872139"},{"key":"e_1_2_8_23_1","first-page":"981","volume":"15","author":"Kang O H","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-137"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020470"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021787"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03601.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1553-1560.2005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737741"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2693"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.8.79"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0493008"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.04.020"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2012.20.5.433"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1206753"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0809532"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0114-005RR"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01224.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0072378"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.79"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12931","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:18:41Z","timestamp":1695493121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/exd.12931"],"URL":"https:\/\/doi.org\/10.1111\/exd.12931","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}