{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:37:07Z","timestamp":1790487427447,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072502"],"award-info":[{"award-number":["81072502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371729"],"award-info":[{"award-number":["81371729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>\n \n The decrease of forkhead box P3\u2010positive (\n FOXP<\/jats:styled-content>\n 3 + ) regulatory T cells (Tregs) causes an immune imbalance with effector T cells in psoriasis. Previous studies have demonstrated that in addition to its known effects on keratinocytes and effector T cells, ultraviolet (\n UV<\/jats:styled-content>\n ) irradiation alleviates psoriasis via the upregulation of\n FOXP<\/jats:styled-content>\n 3 + Tregs. However, the mechanism is unclear. Here, we found that\n FOXP<\/jats:styled-content>\n 3 + T cells were increased in psoriatic lesions after\n UVB<\/jats:styled-content>\n irradiation (\n t<\/jats:italic>\n ' = 3.7006,\n P<\/jats:italic>\n < 0.01), as determined by immunohistochemical staining. In addition, the levels of\n FOXP<\/jats:styled-content>\n 3 and p53, one of the downstream targets of\n UV<\/jats:styled-content>\n irradiation, showed accordant changes after\n UV<\/jats:styled-content>\n irradiation. Experiments that used a\n MAPK<\/jats:styled-content>\n inhibitor, p53 mutant cell lines, p53 inhibitor and p53 sh\n RNA<\/jats:styled-content>\n showed a decrease in\n FOXP<\/jats:styled-content>\n 3 levels, suggesting that p53 is required for\n UV<\/jats:styled-content>\n \u2010induced\n \n FOXP<\/jats:styled-content>\n 3\n <\/jats:italic>\n transcription. Next, we demonstrated that there are two binding sites for p53 on\n \n FOXP<\/jats:styled-content>\n 3\n <\/jats:italic>\n by informatics tools, a dual\u2010luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay. One binding site (\u22121771 to \u22121583) is located at the promoter region and is adjacent to a previously reported p53\u2010binding region in breast cancer cells. The other (+3845 to +4042) is located within the first intron and has not been previously reported. Our study demonstrated that\n FOXP<\/jats:styled-content>\n 3 is regulated, at least in part, by the binding of p53 to several binding sites in the promoter and intron regions following\n UV<\/jats:styled-content>\n irradiation in psoriasis. It will be helpful to further clarify the regulatory mechanism of\n \n FOXP<\/jats:styled-content>\n 3\n <\/jats:italic>\n transcription and to provide new insights into the mechanisms that mediate the effects of UV irradiation in autoimmune skin disorders.\n <\/jats:p>","DOI":"10.1111\/exd.12942","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T06:51:01Z","timestamp":1453186261000},"page":"513-518","source":"Crossref","is-referenced-by-count":27,"title":["Ultraviolet irradiation promotes\n FOXP3<\/i>\n transcription via p53 in psoriasis"],"prefix":"10.1111","volume":"25","author":[{"given":"Dongmei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Daping Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine University of California, Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.164"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2889"},{"key":"e_1_2_10_4_1","first-page":"647","volume":"13","author":"Gatzka M","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2402"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.07919.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10149.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1530-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12369"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00616.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903719"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.04.062"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181aed927"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.01.024"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.02.015"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.04.015"},{"key":"e_1_2_10_18_1","first-page":"257","volume":"5","author":"Guan N","year":"2007","journal-title":"Chin J Derm Venereol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12575"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300509"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2730"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03648.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.047985"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.034"},{"key":"e_1_2_10_25_1","first-page":"3765","volume":"117","author":"Zuo T","year":"2007","journal-title":"J Clin Invest"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-210393"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006527"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.10.018"},{"key":"e_1_2_10_29_1","first-page":"2190","volume":"2013","author":"Shen Z","year":"1833","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20152"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.06.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00294"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12104"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.08.048"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21056"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23747.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1096\/fj.04-2285fje","volume":"18","author":"Laethem A","year":"2004","journal-title":"FASEB J"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050038"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070109"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838105"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203473"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.053"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-055756"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.030"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.031"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1445"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05543"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12942","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T03:38:31Z","timestamp":1695526711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/exd.12942"],"URL":"https:\/\/doi.org\/10.1111\/exd.12942","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726085173.793520285","asserted-by":"object"}]},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}