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When activated,\n                    <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>\n                    s are capable of producing large quantities of type I\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    s (mainly\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ), which provide antiviral resistance and link the innate and adaptive immunity. While generally lacking from normal skin,\n                    <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>\n                    s infiltrate the skin and appear to be involved in the pathogenesis of several inflammatory, infectious (especially viral) and neoplastic entities. In recent years,\n                    <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>\n                    role in inflammatory\/autoimmune skin conditions has been extensively studied. Unlike type I\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010mediated protective immunity that\n                    <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>\n                    s provide at the level of the skin by regulated sensing of microbial or self\u2010nucleic acids upon skin damage, excessive sensing may elicit\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010driven inflammatory\/autoimmune diseases. In this review, focus will be on the role of\n                    <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>\n                    s in cutaneous inflammatory\/autoimmune dermatoses.\n                  <\/jats:p>","DOI":"10.1111\/exd.12957","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T16:23:50Z","timestamp":1454430230000},"page":"415-421","source":"Crossref","is-referenced-by-count":79,"title":["Update on the role of plasmacytoid dendritic cells in inflammatory\/autoimmune skin diseases"],"prefix":"10.1111","volume":"25","author":[{"given":"Dana","family":"Saadeh","sequence":"first","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Kurban","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut 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