{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:40:39Z","timestamp":1768455639892,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24659835"],"award-info":[{"award-number":["24659835"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18591995"],"award-info":[{"award-number":["18591995"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported that allergic responses to nickel (Ni) were minimal in mice deficient in the histamine\u2010forming enzyme histidine decarboxylase (<jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>), suggesting an involvement of histamine in allergic responses to Ni. However, it remains unclear how histamine is involved in the process of Ni allergy. Here, we examined the role of histamine in Ni allergy using a murine model previously established by us. Mice were sensitized to Ni by intraperitoneal injection of a NiCl<jats:sub>2<\/jats:sub>\u2010lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) mixture. Ten days later, allergic inflammation was elicited by challenging ear\u2010pinnas intradermally with NiCl<jats:sub>2<\/jats:sub>. Then, ear\u2010swelling was measured. Pyrilamine (histamine H1\u2010receptor antagonist) or cromoglicate (mast cell stabilizer) was intravenously injected 1 h before the sensitization or the challenge. In cell\u2010transfer experiments, spleen cells from Ni\u2010sensitized donor mice were intravenously transferred into non\u2010sensitized recipient mice. In both sensitized and non\u2010sensitized mice, 1 m<jats:sc>m<\/jats:sc> or more NiCl<jats:sub>2<\/jats:sub> (injected into ear\u2010pinnas) induced transient non\u2010allergic inflammation (Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>) with accompanying mast cell degranulation. <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> did not affect the magnitude of this Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>. Pyrilamine and cromoglicate reduced either the Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> or the ensuing allergic inflammation when administered <jats:italic>before<\/jats:italic> Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> (at either the sensitization or elicitation step), but not if administered when the Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> had subsided. Experiments on <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> and H1\u2010receptor\u2010<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mice, and also cell\u2010transfer experiments using these mice, demonstrated histamine's involvement in both the sensitization and elicitation steps. These results suggest that mast cell histamine\u2010mediated Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> promotes subsequent allergic inflammatory responses to Ni, raising the possibility that control of Ni\u2010<jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> by drugs may be effective at preventing or reducing Ni allergy.<\/jats:p>","DOI":"10.1111\/exd.12985","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T03:49:57Z","timestamp":1456372197000},"page":"466-471","source":"Crossref","is-referenced-by-count":11,"title":["Mast cell histamine\u2010mediated transient inflammation following exposure to nickel promotes nickel allergy in mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Masayuki","family":"Kinbara","sequence":"first","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"},{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanan","family":"Bando","sequence":"additional","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"},{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinobu","family":"Kuroishi","sequence":"additional","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Department of Applied Quantum Medical Engineering School of Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruko","family":"Takano\u2010Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Molecular Regulation Graduate School of Dentistry Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00107.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04034.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx9002726"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.3.1143"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235491"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1067\/mjd.2000.102457","volume":"43","author":"Adachi A","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30551-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04437.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00340.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-6938.2001.00963.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630152696107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02705.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10468.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10016.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102617"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(92)90086-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2003.10.011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050624"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03374.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.673"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00395-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1585"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00696-X"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35096564"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.028"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/839682"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(95)80056-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20022180"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.015"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13316"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02663-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700726"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.4.1398"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.129"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2782"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1158"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1460"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486217"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60577-5"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.06.003"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.051"},{"key":"e_1_2_9_44_1","first-page":"3","volume":"2013","author":"Egawa G","year":"1932","journal-title":"Sci Rep"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1503"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080407"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1994.tb01766.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425909341070"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.05.010"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.07.025"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552674"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1919"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90157-0"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.116"},{"key":"e_1_2_9_55_1","first-page":"717","volume-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","author":"Undem B J","year":"2006"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343838"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1990.tb01501.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12985","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:37:16Z","timestamp":1695541036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/exd.12985"],"URL":"https:\/\/doi.org\/10.1111\/exd.12985","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]}}}