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Activation of the serotonin (5\u2010hydroxytryptamine, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) pathway has been suggested to be involved in the modulation of T\u2010cell responses and found to mediate <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010induced immune suppression. In particular, the activation of the 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>2A<\/jats:sub> receptor has been proposed as one mechanism responsible for <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced immune suppression. We therefore hypothesized that 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> may play a role in <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>\u2010induced effects. The model of systemic suppression of delayed\u2010type hypersensitivity (<jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content>) to <jats:italic>Candida albicans<\/jats:italic> was used to study immune function after exposure of C3H and <jats:styled-content style=\"fixed-case\">KIT<jats:sup><jats:italic>W<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>\u2010Sh\/W\u2010Sh<\/jats:italic><\/jats:sup> mice to a minimal inflammatory dose of topical <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>. The intra\u2010peritoneal injection of the 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>2<\/jats:sub> receptor antagonist ketanserin or cyproheptadine or an anti\u20105\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> antibody immediately before <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> exposure entirely abrogated suppression of <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> but had no significant effect on inflammation, as measured by swelling and cellular infiltration of the skin, and apoptosis as determined by the number of sunburn cells in C3H mice. Importantly, the systemic injection of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> recapitulated <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> immune suppression of <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> but did not induce inflammation or apoptosis in the skin. <jats:styled-content style=\"fixed-case\">KIT<jats:sup><jats:italic>W<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>\u2010Sh\/W\u2010Sh<\/jats:italic><\/jats:sup> mice (exhibiting myelopoietic abnormalities, including lack of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\u2010containing mast cells) were resistant to <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>\u2010induced suppression of <jats:styled-content style=\"fixed-case\">DTH<\/jats:styled-content> but not local skin swelling. Thus, this points towards a crucial role of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> signalling in <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>\u2010induced immune suppression but not inflammation or apoptosis <jats:italic>in\u00a0situ<\/jats:italic> in the skin.<\/jats:p>","DOI":"10.1111\/exd.12990","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:16:36Z","timestamp":1456456596000},"page":"537-543","source":"Crossref","is-referenced-by-count":11,"title":["Serotonin signalling is crucial in the induction of <scp>PUVA<\/scp>\u2010induced systemic suppression of delayed\u2010type hypersensitivity but not local apoptosis or inflammation of the skin"],"prefix":"10.1111","volume":"25","author":[{"given":"Peter","family":"Wolf","sequence":"first","affiliation":[{"name":"Research Unit for Photodermatology Department of Dermatology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott N.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Cellular Photoimmunology Group, Infectious Diseases and Immunology Sydney Medical School The Charles Perkins Centre at The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Y.","family":"Limon\u2010Flores","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology Faculty of Medicine Universidad Autonoma de Nuevo Le\u00f3n Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Hoefler","sequence":"additional","affiliation":[{"name":"Institute for Pathology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Immunology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02898.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.405"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060079"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1989.tb04151.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12478010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12542071"},{"key":"e_1_2_9_8_1","first-page":"116","volume":"8","author":"Ullrich S E","year":"1991","journal-title":"Photodermatol Photoimmunol 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