{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T04:00:58Z","timestamp":1778385658363,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (<jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content>) has been associated with improved wound healing and scarless repair. In this study, we have investigated the consequences of <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content> deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content> in both human and murine fibrotic skin. In the bleomycin model\u00a0of skin fibrosis, <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> mice developed skin fibrosis\u00a0to a similar degree compared to <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content><jats:sup>+\/+<\/jats:sup> mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril\u00a0diameter in <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> but not <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content><jats:sup>+\/+<\/jats:sup> mice following\u00a0fibrosis. We conclude that the impact of <jats:styled-content style=\"fixed-case\">FMOD<\/jats:styled-content> deficiency on the development of experimental skin fibrosis is limited.<\/jats:p>","DOI":"10.1111\/exd.13012","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T17:50:01Z","timestamp":1458582601000},"page":"558-561","source":"Crossref","is-referenced-by-count":6,"title":["Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis"],"prefix":"10.1111","volume":"25","author":[{"given":"Kristofer","family":"Andr\u00e9asson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Section\u00a0of Rheumatology and Molecular Skeletal Biology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Rydell\u2010T\u00f6rm\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"Westergren\u2010Thorsson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore","family":"Saxne","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Section\u00a0of Rheumatology and Molecular Skeletal Biology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Hesselstrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Section\u00a0of Rheumatology and Molecular Skeletal Biology Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31139"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2010.01.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06383"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00677.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3182335980"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0148-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64555-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.05.004"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:39:23Z","timestamp":1695541163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,29]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/exd.13012"],"URL":"https:\/\/doi.org\/10.1111\/exd.13012","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,29]]}}}