{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:13:28Z","timestamp":1791213208441,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005736","name":"Universit\u00e9 Paris Diderot","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 has been implicated in melanoma invasion and metastasis mainly through increasing metalloproteinase synthesis and regulating <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content> signalling. In this study, the prognostic value of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 expression was investigated in a cohort of 196 cutaneous melanomas including 136 consecutive primary malignant melanomas, 30 lymph nodes, 16 in\u2010transit and 14 visceral metastases. A series of 10 normal skin, 10 blue nevi and 10 dermal nevi was used as control. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 expression was assessed by immunohistochemistry, and the association of its expression with the clinicopathological characteristics of patients and survival was evaluated using univariate and multivariate statistical analyses. Univariate analysis showed that high <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 expression was significantly associated with metastatic potential and with a reduced overall survival (<jats:italic>P<\/jats:italic> &lt; 0.05 for both) in primary melanoma patients. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 expression level was correlated with histological factors which were associated with prognosis: Clark level, ulceration status and more particularly with Breslow index (<jats:italic>r<\/jats:italic> = 0.7, <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22128<\/jats:sup>). Multivariate analysis retained <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 expression level and ulceration status as predicting factors for metastasis and overall survival (<jats:italic>P<\/jats:italic> &lt; 0.05 for both). <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>147 emerges as an important factor in the aggressive behaviour of melanoma and deserves further evaluation as an independent prognostic biomarker.<\/jats:p>","DOI":"10.1111\/exd.13022","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T14:58:51Z","timestamp":1460300331000},"page":"618-622","source":"Crossref","is-referenced-by-count":19,"title":["EMMPRIN\/CD147 is an independent prognostic biomarker in cutaneous melanoma"],"prefix":"10.1111","volume":"25","author":[{"given":"Anne","family":"Caudron","sequence":"first","affiliation":[{"name":"Inserm U 976 Paris 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