{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:58:13Z","timestamp":1789372693842,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES020965"],"award-info":[{"award-number":["ES020965"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR063781"],"award-info":[{"award-number":["AR063781"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hairless albino Crl:<jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1<jats:italic>\u2010Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup> mice are commonly utilized for studies in which hair or pigmentation would introduce an impediment to observational studies. Being an outbred strain, the <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 model suffers from key limitations that are not seen with congenic mouse strains. Inbred and congenic C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice are commonly utilized for modified genetic mouse models. We compare the acute <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced photoresponse between outbred <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 mice and an immune competent, hairless, albino C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J congenic mouse line [B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J]. Histologically, B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J skin is indistinguishable from that of <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 mice. The skin of both <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 and B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J mice exhibited a reduction in hypodermal adipose tissue, the presence of utricles and dermal cystic structures, the presence of dermal granulomas and epidermal thickening. In response to a single 1500 J\/m<jats:sup>2<\/jats:sup> ultraviolet B dose, the oedema and apoptotic responses were equivalent in both mouse strains. However, B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J mice exhibited a more robust delayed sunburn reaction, with an increase in epidermal erosion, scab formation and myeloperoxidase activity relative to <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 mice. Compared with <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 mice, B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J also exhibited an aberrant proliferative response to this single <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposure. Epidermal Ki67 immunopositivity was significantly suppressed in B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J mice at 24 h post\u2010<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>. A smaller non\u2010significant reduction in Ki67 labelling was observed in <jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>1 mice. Finally, at 72 h post\u2010<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SKH<\/jats:styled-content>1 mice, but not B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J mice, exhibited a significant increase in Ki67 immunolabelling relative to non\u2010irradiated controls. Thus, B6.<jats:italic>Cg\u2010Tyr<\/jats:italic><jats:sup><jats:italic>c\u22122J<\/jats:italic><\/jats:sup> <jats:italic>Hr<\/jats:italic><jats:sup><jats:italic>hr<\/jats:italic><\/jats:sup>\/J mice are suitable for photobiology experiments.<\/jats:p>","DOI":"10.1111\/exd.13034","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T10:12:09Z","timestamp":1461147129000},"page":"688-693","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of the acute ultraviolet photoresponse in congenic albino hairless C57<scp>BL<\/scp>\/6J mice relative to outbred <scp>SKH<\/scp>1 hairless mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Raymond L.","family":"Konger","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"},{"name":"Department of Dermatology Indiana University School of Medicine Indianapolis IN 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