{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:37:35Z","timestamp":1781829455040,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Actinic keratoses (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s) commonly arise on sun\u2010damaged skin. Visible lesions are often associated with subclinical lesions on surrounding skin, giving rise to field cancerization. To avoid multiple biopsies to diagnose subclinical\/early invasive lesions, there is an increasing interest in non\u2010invasive diagnostic tools, such as high\u2010definition optical coherence tomography (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>). We previously developed a <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\u2010based diagnostic algorithm for the discrimination of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> from squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) and normal skin. The aim of this study was to test the applicability of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> for non\u2010invasive discrimination of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> and normal skin using this algorithm. Three\u2010dimensional (3D) <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images of histopathologically proven <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s and images of normal skin were collected. All images were shown in a random sequence to three independent observers with different experience in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>, blinded to the clinical and histopathological data and with different experience with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. Observers classified each image as <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SCC<\/jats:styled-content> or normal skin based on the diagnostic algorithm. A total of 106 (38 <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s, 16 <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s and 52 normal skin sites) <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images from 71 patients were included. Sensitivity and specificity for the most experienced observer were 81.6% and 92.6% for <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> diagnosis and 93.8% and 98.9% for <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> diagnosis. A moderate interobserver agreement was demonstrated. <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> represents a promising technology for the non\u2010invasive diagnosis of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s. Thanks to its high potential in discriminating <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> could be used as a relevant tool for second\u2010level examination, increasing diagnostic confidence and sparing patients unnecessary excisions.<\/jats:p>","DOI":"10.1111\/exd.13036","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T10:13:11Z","timestamp":1461147191000},"page":"684-687","source":"Crossref","is-referenced-by-count":32,"title":["Validation of a diagnostic algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma by means of high\u2010definition optical coherence tomography"],"prefix":"10.1111","volume":"25","author":[{"given":"Alice","family":"Marneffe","sequence":"first","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Del Marmol","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Boone","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57415"},{"key":"e_1_2_9_3_1","first-page":"462","volume":"4","author":"Cockerell C J","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103342"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.134"},{"key":"e_1_2_9_6_1","volume-title":"Solar ultraviolet radiation: Global burden of disease from solar ultraviolet radiation; 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