{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:24:04Z","timestamp":1783607044120,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["101761"],"award-info":[{"award-number":["101761"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["105369"],"award-info":[{"award-number":["105369"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Acne is a common skin disease characterized by elevated sebum production and inflammation of the sebaceous glands. We have previously shown that a non\u2010psychotropic phytocannabinoid ((\u2013)\u2010cannabidiol [CBD<\/jats:styled-content>]) exerted complex anti\u2010acne effects by normalizing \u2018pro\u2010acne agents\u2019\u2010induced excessive sebaceous lipid production, reducing proliferation and alleviating inflammation in human SZ<\/jats:styled-content>95 sebocytes. Therefore, in this study we aimed to explore the putative anti\u2010acne effects of further non\u2010psychotropic phytocannabinoids ((\u2013)\u2010cannabichromene [CBC<\/jats:styled-content>], (\u2013)\u2010cannabidivarin [CBDV<\/jats:styled-content>], (\u2013)\u2010cannabigerol [CBG<\/jats:styled-content>], (\u2013)\u2010cannabigerovarin [CBGV<\/jats:styled-content>] and (\u2013)\u2010\u03949<\/jats:sup>\u2010tetrahydrocannabivarin [THCV<\/jats:styled-content>]). Viability and proliferation of human SZ<\/jats:styled-content>95 sebocytes were investigated by MTT<\/jats:styled-content> and CyQUANT<\/jats:styled-content> assays; cell death and lipid synthesis were monitored by DilC1<\/jats:sub>(5)\u2010SYTOX<\/jats:styled-content> Green labelling and Nile Red staining, respectively. Inflammatory responses were investigated by monitoring expressions of selected cytokines upon lipopolysaccharide treatment (RT<\/jats:styled-content>\u2010qPCR<\/jats:styled-content>, ELISA<\/jats:styled-content>). Up to 10 \u03bc<\/jats:italic>m<\/jats:sc>, the phytocannabinoids only negligibly altered the viability of the sebocytes, whereas high doses (\u226550 \u03bc<\/jats:italic>m<\/jats:sc>) induced apoptosis. Interestingly, basal sebaceous lipid synthesis was differentially modulated by the substances: CBC<\/jats:styled-content> and THCV<\/jats:styled-content> suppressed it, and CBDV<\/jats:styled-content> had only minor effects, whereas CBG<\/jats:styled-content> and CBGV<\/jats:styled-content> increased it. Importantly, CBC<\/jats:styled-content>, CBDV<\/jats:styled-content> and THCV<\/jats:styled-content> significantly reduced arachidonic acid (AA<\/jats:styled-content>)\u2010induced \u2018acne\u2010like\u2019 lipogenesis. Moreover, THCV<\/jats:styled-content> suppressed proliferation, and all phytocannabinoids exerted remarkable anti\u2010inflammatory actions. Our data suggest that CBG<\/jats:styled-content> and CBGV<\/jats:styled-content> may have potential in the treatment of dry\u2010skin syndrome, whereas CBC<\/jats:styled-content>, CBDV<\/jats:styled-content> and especially THCV<\/jats:styled-content> show promise to become highly efficient, novel anti\u2010acne agents. Moreover, based on their remarkable anti\u2010inflammatory actions, phytocannabinoids could be efficient, yet safe novel tools in the management of cutaneous inflammations.<\/jats:p>","DOI":"10.1111\/exd.13042","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T10:22:58Z","timestamp":1461147778000},"page":"701-707","source":"Crossref","is-referenced-by-count":101,"title":["Differential effectiveness of selected non\u2010psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry\/seborrhoeic skin and acne treatment"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-5639","authenticated-orcid":false,"given":"Attila","family":"Ol\u00e1h","sequence":"first","affiliation":[{"name":"DE\u2010MTA \u2018Lend\u00fclet\u2019 Cellular Physiology Research Group Department of Physiology Faculty of Medicine University of Debrecen Debrecen 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